Synthesis of tritium labeled KRN7000

Martijn D.P. Risseeuw; Celia R. Berkers; Hidde L. Ploegh; Huib Ovaa

doi:10.1016/j.tetlet.2006.03.131

Synthesis of tritium labeled KRN7000

Martijn D.P. Risseeuw
, Celia R. Berkers
, Hidde L. Ploegh
, Huib Ovaa

Brigham and Women's Hospital and Harvard Medical School

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The synthesis of a multiple tritiated analog of KRN7000 (α-galactosyl ceramide) is described, enabling further studies to quantitate the affinity of KRN7000 for its receptor and to study its pharmacokinetic properties. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3677-3679
Number of pages	3
Journal	Tetrahedron Letters
Volume	47
Issue number	22
DOIs	https://doi.org/10.1016/j.tetlet.2006.03.131
Publication status	Published - 29 May 2006
Externally published	Yes

Keywords

1 o (alpha galactopyranosyl) 2 hexacosanoylamino 1,3,4 octadecanetriol
receptor
tritium
article
binding affinity
drug synthesis
quantitative analysis

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10.1016/j.tetlet.2006.03.131

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title = "Synthesis of tritium labeled KRN7000",

abstract = "The synthesis of a multiple tritiated analog of KRN7000 (α-galactosyl ceramide) is described, enabling further studies to quantitate the affinity of KRN7000 for its receptor and to study its pharmacokinetic properties. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

keywords = "1 o (alpha galactopyranosyl) 2 hexacosanoylamino 1,3,4 octadecanetriol, receptor, tritium, article, binding affinity, drug synthesis, quantitative analysis",

author = "Risseeuw, \{Martijn D.P.\} and Berkers, \{Celia R.\} and Ploegh, \{Hidde L.\} and Huib Ovaa",

year = "2006",

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doi = "10.1016/j.tetlet.2006.03.131",

language = "English",

volume = "47",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of tritium labeled KRN7000

AU - Risseeuw, Martijn D.P.

AU - Berkers, Celia R.

AU - Ploegh, Hidde L.

AU - Ovaa, Huib

PY - 2006/5/29

Y1 - 2006/5/29

N2 - The synthesis of a multiple tritiated analog of KRN7000 (α-galactosyl ceramide) is described, enabling further studies to quantitate the affinity of KRN7000 for its receptor and to study its pharmacokinetic properties. © 2006 Elsevier Ltd. All rights reserved.

AB - The synthesis of a multiple tritiated analog of KRN7000 (α-galactosyl ceramide) is described, enabling further studies to quantitate the affinity of KRN7000 for its receptor and to study its pharmacokinetic properties. © 2006 Elsevier Ltd. All rights reserved.

KW - 1 o (alpha galactopyranosyl) 2 hexacosanoylamino 1,3,4 octadecanetriol

KW - receptor

KW - tritium

KW - article

KW - binding affinity

KW - drug synthesis

KW - quantitative analysis

U2 - 10.1016/j.tetlet.2006.03.131

DO - 10.1016/j.tetlet.2006.03.131

M3 - Article

SN - 0040-4039

VL - 47

SP - 3677

EP - 3679

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

Synthesis of tritium labeled KRN7000

Abstract

Keywords

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