Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity

Z. Eskandariyan; M. Esfahani Zadeh; Kamaleddin Hajmohammadebrahimtehrani; V. Mashayekhi; F. Kobarfard

doi:10.1007/s12272-013-0192-5

Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity

Z. Eskandariyan, M. Esfahani Zadeh, Kamaleddin Hajmohammadebrahimtehrani, V. Mashayekhi, F. Kobarfard

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Abstract

A series of 2-(arylmethylthio)-3-phenylquinazolin-4-one derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma. Among the tested thioethers, derivative 2, 3, 5 and 16 were the most potent compounds with satisfactory IC50 for inhibition of platelet aggregation induced by ADP. Analysis of global physicochemical parameters shows some correlations between activities and molecular volume and also surface area of the studied derivatives.

Original language	English
Pages (from-to)	332-339
Journal	Archives of Pharmacal Research
Volume	37
Issue number	3
DOIs	https://doi.org/10.1007/s12272-013-0192-5
Publication status	Published - 2014

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title = "Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity",

abstract = "A series of 2-(arylmethylthio)-3-phenylquinazolin-4-one derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma. Among the tested thioethers, derivative 2, 3, 5 and 16 were the most potent compounds with satisfactory IC50 for inhibition of platelet aggregation induced by ADP. Analysis of global physicochemical parameters shows some correlations between activities and molecular volume and also surface area of the studied derivatives.",

author = "Z. Eskandariyan and {Esfahani Zadeh}, M. and Kamaleddin Hajmohammadebrahimtehrani and V. Mashayekhi and F. Kobarfard",

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doi = "10.1007/s12272-013-0192-5",

language = "English",

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T1 - Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity

AU - Eskandariyan, Z.

AU - Esfahani Zadeh, M.

AU - Hajmohammadebrahimtehrani, Kamaleddin

AU - Mashayekhi, V.

AU - Kobarfard, F.

PY - 2014

Y1 - 2014

N2 - A series of 2-(arylmethylthio)-3-phenylquinazolin-4-one derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma. Among the tested thioethers, derivative 2, 3, 5 and 16 were the most potent compounds with satisfactory IC50 for inhibition of platelet aggregation induced by ADP. Analysis of global physicochemical parameters shows some correlations between activities and molecular volume and also surface area of the studied derivatives.

AB - A series of 2-(arylmethylthio)-3-phenylquinazolin-4-one derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma. Among the tested thioethers, derivative 2, 3, 5 and 16 were the most potent compounds with satisfactory IC50 for inhibition of platelet aggregation induced by ADP. Analysis of global physicochemical parameters shows some correlations between activities and molecular volume and also surface area of the studied derivatives.

U2 - 10.1007/s12272-013-0192-5

DO - 10.1007/s12272-013-0192-5

M3 - Article

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VL - 37

SP - 332

EP - 339

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity

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