Synthesis of Periphery-Functionalized Dendritic Molecules Using Polylithiated Dendrimers as Starting Material

Peter Wijkens, J. T B H Jastrzebski, Paul A. Van Der Schaaf, Roman Kolly, Andreas Hafner, Gerard Van Koten*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    (Matrix Presented) A general method for the functionalization of Si-Cl terminated carbosilane dendritic molecules via organolithium or organomagnesium reagents is described. Quantitative exchange of the bromine atoms of 4-bromophenyl-functionalized dendrimers affords polylithiated species that are valuable starting materials for further functionalization, e.g., into pyridyl alcohols. The latter were successfully applied as catalyst precursors in a ruthenium-mediated ring-closure metathesis reaction.

    Original languageEnglish
    Pages (from-to)1621-1624
    Number of pages4
    JournalOrganic Letters
    Volume2
    Issue number11
    Publication statusPublished - 1 Jun 2000

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