Abstract
Hydroxymethylation of correctly protected alkyl α‐D‐manno‐hexodialdo‐1,5‐pyranosides with [(isopropoxydimethylsilyl)methyl]magnesium chloride affords the corresponding silane intermediates, the isopropoxydimethylsilyl group of which can be unmasked with hydrogen peroxide. The L‐glycero‐α‐D‐manno‐heptopyranose (L‐α‐D‐Hepp) derivatives thus obtained can be subsequently used for the preparation of the disaccharides β‐D‐Glcp‐(1‐4)‐L‐α‐D‐Hepp‐OMe and β‐D‐Glcp‐(1‐4)‐L‐α‐D‐Hepp‐O‐(CH2)3NH2.
Original language | English |
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Pages (from-to) | 339-343 |
Number of pages | 5 |
Journal | Recueil des Travaux Chimiques des Pays‐Bas |
Volume | 108 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Jan 1989 |
Externally published | Yes |