Abstract
This review surveys developments in the field of ring-closing metathesis
and cross-metathesis reactions applied to the synthesis of constrained amino acids,
peptides, and peptidomimetics. Examples, in which metathesis is used as one of the
synthetic tools to arrive at the desired peptide molecules as well as examples that
describe in-depth optimized metathesis protocols, will be discussed. Currently,
metathesis reactions are well-accepted synthetic tools within the field of peptide
chemistry and provide peptides unprecedented properties like conformational,
metabolic, and chemical stability and improved bioactivity.
and cross-metathesis reactions applied to the synthesis of constrained amino acids,
peptides, and peptidomimetics. Examples, in which metathesis is used as one of the
synthetic tools to arrive at the desired peptide molecules as well as examples that
describe in-depth optimized metathesis protocols, will be discussed. Currently,
metathesis reactions are well-accepted synthetic tools within the field of peptide
chemistry and provide peptides unprecedented properties like conformational,
metabolic, and chemical stability and improved bioactivity.
Original language | English |
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Title of host publication | Topics in Heterocyclic Chemistry |
Publisher | Springer |
Number of pages | 54 |
DOIs | |
Publication status | Published - 2015 |
Publication series
Name | Topics in Heterocyclic Chemistry |
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ISSN (Print) | 1861-9282 |