Synthesis of arylzinc thiolates containing perfluoroalkyl chains. Model catalyst precursors for the enantioselective zinc-mediated 1,2-addition of dialkylzincs to aldehydes in fluorous biphase systems

Henk Kleijn, Evelien Rijnberg, J. T B H Jastrzebski, Gerard Van Koten*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    (equation presented) The synthesis of perfluoroalkyl-functionalized arene trimethylsilyl ethers and their conversion to ethylzinc thiolates is described. These compounds have been successfully applied as catalysts in the enantioselective addition of diethylzinc to benzaldehyde. This is the first example of a two-phase organic/perfluorous enantioselective catalytic system.

    Original languageEnglish
    Pages (from-to)853-855
    Number of pages3
    JournalOrganic Letters
    Volume1
    Issue number6
    Publication statusPublished - 23 Sept 1999

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