Synthesis of a potential inhibitor of UDP-glucuronosyltransferase

D. Noort; N. C R van Straten; G. J P H Boons; G. A. van der Marel; X. Bossuyt; N. Blanckaert; G. J. Mulder; J. H. van Boom

doi:10.1016/S0960-894X(01)81202-6

Synthesis of a potential inhibitor of UDP-glucuronosyltransferase

D. Noort^*
, N. C R van Straten
, G. J P H Boons
, G. A. van der Marel
, X. Bossuyt
, N. Blanckaert
, G. J. Mulder
, J. H. van Boom

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A convenient synthesis of phosphonomethyl 1-O-(2,2,2-triphenyl)ethyl-α-D-gluco-2-heptulopyranosiduronate (2) is presented. The target compound proved to be an inhibitor of UDP-glucuronosyltransferase in vitro.

Original language	English
Pages (from-to)	583-588
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(01)81202-6
Publication status	Published - 1 Jan 1992
Externally published	Yes

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10.1016/S0960-894X(01)81202-6

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title = "Synthesis of a potential inhibitor of UDP-glucuronosyltransferase",

abstract = "A convenient synthesis of phosphonomethyl 1-O-(2,2,2-triphenyl)ethyl-α-D-gluco-2-heptulopyranosiduronate (2) is presented. The target compound proved to be an inhibitor of UDP-glucuronosyltransferase in vitro.",

author = "D. Noort and \{van Straten\}, \{N. C R\} and Boons, \{G. J P H\} and \{van der Marel\}, \{G. A.\} and X. Bossuyt and N. Blanckaert and Mulder, \{G. J.\} and \{van Boom\}, \{J. H.\}",

year = "1992",

month = jan,

day = "1",

doi = "10.1016/S0960-894X(01)81202-6",

language = "English",

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pages = "583--588",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis of a potential inhibitor of UDP-glucuronosyltransferase

AU - Noort, D.

AU - van Straten, N. C R

AU - Boons, G. J P H

AU - van der Marel, G. A.

AU - Bossuyt, X.

AU - Blanckaert, N.

AU - Mulder, G. J.

AU - van Boom, J. H.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A convenient synthesis of phosphonomethyl 1-O-(2,2,2-triphenyl)ethyl-α-D-gluco-2-heptulopyranosiduronate (2) is presented. The target compound proved to be an inhibitor of UDP-glucuronosyltransferase in vitro.

AB - A convenient synthesis of phosphonomethyl 1-O-(2,2,2-triphenyl)ethyl-α-D-gluco-2-heptulopyranosiduronate (2) is presented. The target compound proved to be an inhibitor of UDP-glucuronosyltransferase in vitro.

UR - https://www.scopus.com/pages/publications/0026737589

U2 - 10.1016/S0960-894X(01)81202-6

DO - 10.1016/S0960-894X(01)81202-6

M3 - Article

AN - SCOPUS:0026737589

SN - 0960-894X

VL - 2

SP - 583

EP - 588

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis of a potential inhibitor of UDP-glucuronosyltransferase

Abstract

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