Synaptobrevin, sphingolipids, and secretion: lube 'n' go at the synapse

M. Verhage, G. van Meer

Research output: Contribution to journalArticleAcademicpeer-review


For neurotransmitter release to occur, proteins and lipids have to work together. The classical view of this process is that a variety of proteins work hard to force the unwilling, fusion-aversive lipids into merging. In this issue of Neuron, a study by Darios et al. paints the opposite picture: a lipid metabolite stimulates the reluctant vSNARE synaptobrevin to engage in fusogenic protein complexes.
Original languageUndefined/Unknown
Pages (from-to)603-605
Number of pages3
Publication statusPublished - 2009

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