Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.

E. Stokvis; H. Rosing; L. Lopez-Lazaro; J.H.M. Schellens; J.H. Beijnen

Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.

E. Stokvis
, H. Rosing
, L. Lopez-Lazaro
, J.H.M. Schellens
, J.H. Beijnen

extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC-MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC-MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC-MS/MS assays of drugs in biological matrices.

Original language	Undefined/Unknown
Pages (from-to)	400-2
Number of pages	3
Journal	Biomedical Chromatography
Volume	18
Issue number	6
Publication status	Published - 2004

Cite this

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title = "Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.",

abstract = "The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC-MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC-MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC-MS/MS assays of drugs in biological matrices.",

author = "E. Stokvis and H. Rosing and L. Lopez-Lazaro and J.H.M. Schellens and J.H. Beijnen",

year = "2004",

language = "Undefined/Unknown",

volume = "18",

pages = "400--2",

journal = "Biomedical Chromatography",

issn = "0269-3879",

publisher = "John Wiley and Sons Ltd",

number = "6",

}

Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance. / Stokvis, E.; Rosing, H.; Lopez-Lazaro, L. et al.
In: Biomedical Chromatography, Vol. 18, No. 6, 2004, p. 400-2.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.

AU - Stokvis, E.

AU - Rosing, H.

AU - Lopez-Lazaro, L.

AU - Schellens, J.H.M.

AU - Beijnen, J.H.

PY - 2004

Y1 - 2004

N2 - The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC-MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC-MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC-MS/MS assays of drugs in biological matrices.

AB - The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC-MS/MS assay for Kahalalide F in human plasma is highlighted. Similar results can be expected for other LC-MS/MS assays. Therefore, we emphasize the need for an SIL internal standard for accurate and precise LC-MS/MS assays of drugs in biological matrices.

M3 - Article

SN - 0269-3879

VL - 18

SP - 400

EP - 402

JO - Biomedical Chromatography

JF - Biomedical Chromatography

IS - 6

ER -