Switchable Electrostatically Templated Polymerization

Chendan Li; Jose R. Magana; Fabian Sobotta; Junyou Wang; Martien A.Cohen Stuart; Bas G.P. van Ravensteijn; Ilja K. Voets

doi:10.1002/anie.202206780

Switchable Electrostatically Templated Polymerization

Chendan Li, Jose R. Magana, Fabian Sobotta, Junyou Wang, Martien A.Cohen Stuart, Bas G.P. van Ravensteijn^*, Ilja K. Voets^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We report a switchable, templated polymerization system where the strength of the templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through a dendritic polyamidoamine-based template of which the charge density depends on pH. The dendrimers act as a template for the polymerization of an oppositely charged monomer, namely sodium styrene sulfonate. We show that the rate of polymerization and maximum achievable monomer conversion are directly related to the charge density of the template, and hence the environmental pH. The polymerization could effectively be switched “ON” and “OFF” on demand, by cycling between acidic and alkaline reaction environments. These findings break ground for a novel concept, namely harnessing co-assembly of a template and growing polymer chains with tunable association strength to create and control coupled polymerization and self-assembly pathways of (charged) macromolecular building blocks.

Original language	English
Article number	e202206780
Pages (from-to)	1-6
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	61
Issue number	39
DOIs	https://doi.org/10.1002/anie.202206780
Publication status	Published - 26 Sept 2022

Bibliographical note

Funding Information:
This work was financially supported by the Marie Curie Research Grants Scheme, Grant 838585, STAR Polymers (B.G.P.v.R). C. L. acknowledges the China Scholarship Council for State Scholarship Fund File No.201906740077. I.K.V. acknowledges The Netherlands Organisation for Scientific Research (NWO VIDI Grant 723.014.006, NWO LIFT Grant 731.017.407) for financial support. Javier Sastre Toraño (Utrecht University, Chemical Biology & Drug Discovery) is thanked for performing the MALDI‐TOF‐MS analysis.

Publisher Copyright:
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Funding

This work was financially supported by the Marie Curie Research Grants Scheme, Grant 838585, STAR Polymers (B.G.P.v.R). C. L. acknowledges the China Scholarship Council for State Scholarship Fund File No.201906740077. I.K.V. acknowledges The Netherlands Organisation for Scientific Research (NWO VIDI Grant 723.014.006, NWO LIFT Grant 731.017.407) for financial support. Javier Sastre Toraño (Utrecht University, Chemical Biology & Drug Discovery) is thanked for performing the MALDI‐TOF‐MS analysis.

Keywords

Complex Core Coacervate Micelles
PIESA
Polyelectrolytes
RAFT Polymerization
Templated Polymerizations

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Angew Chem Int Ed - 2022 - Li - Switchable Electrostatically Templated PolymerizationFinal published version, 3.64 MBLicence: CC BY-NC-ND

Cite this

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abstract = "We report a switchable, templated polymerization system where the strength of the templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through a dendritic polyamidoamine-based template of which the charge density depends on pH. The dendrimers act as a template for the polymerization of an oppositely charged monomer, namely sodium styrene sulfonate. We show that the rate of polymerization and maximum achievable monomer conversion are directly related to the charge density of the template, and hence the environmental pH. The polymerization could effectively be switched “ON” and “OFF” on demand, by cycling between acidic and alkaline reaction environments. These findings break ground for a novel concept, namely harnessing co-assembly of a template and growing polymer chains with tunable association strength to create and control coupled polymerization and self-assembly pathways of (charged) macromolecular building blocks.",

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note = "Funding Information: This work was financially supported by the Marie Curie Research Grants Scheme, Grant 838585, STAR Polymers (B.G.P.v.R). C. L. acknowledges the China Scholarship Council for State Scholarship Fund File No.201906740077. I.K.V. acknowledges The Netherlands Organisation for Scientific Research (NWO VIDI Grant 723.014.006, NWO LIFT Grant 731.017.407) for financial support. Javier Sastre Tora{\~n}o (Utrecht University, Chemical Biology & Drug Discovery) is thanked for performing the MALDI‐TOF‐MS analysis. Publisher Copyright: {\textcopyright} 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.",

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Switchable Electrostatically Templated Polymerization

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Keywords

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