Sweet attachment: Structural and functional studies on nidovirus hemagglutinin-esterases

M.J.G. Bakkers

    Research output: ThesisDoctoral thesis 1 (Research UU / Graduation UU)

    Abstract

    The thesis described our investigations in the fields of O-acetylsialoglycobiology
    and the structure and function of corona- and torovirus hemagglutininesterase
    (HE) proteins.
    There are three topics that cover the experimental contents of this thesis:
    i) the distribution and synthesis of O-Ac-sialoglycans
    ii) common principles underlying the structural recognition of O-Ac-Sia by viral proteins
    iii) the dynamic balance of virionglycan interactions by the opposing activities of attachment and release.
    Original languageEnglish
    Awarding Institution
    • Utrecht University
    Supervisors/Advisors
    • van Kuppeveld, Frank, Primary supervisor
    • de Groot, Raoul, Supervisor
    Award date15 Mar 2017
    Publisher
    Print ISBNs978-90-393-6736-0
    Publication statusPublished - 15 Mar 2017

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