Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions

Jun Guo, Guojun Chen, Xinghai Ning, Margreet A. Wolfert, Xiuru Li, Bingqian Xu, Geert Jan Boons*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release. Click to deliver: Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.

Original languageEnglish
Pages (from-to)13360-13366
Number of pages7
JournalChemistry - A European Journal
Volume16
Issue number45
DOIs
Publication statusPublished - 3 Dec 2010
Externally publishedYes

Keywords

  • bioconjugation
  • click chemistry
  • drug delivery
  • nanocarriers
  • scanning probe microscopy

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