Abstract
The evaluation of various types of data and the understanding of their properties is the backbone of scientific work. Time series data are abundant in the investigation of manufacturing processes. Since they result from measurements of parameters over time, time series have distinctive statistical characteristics. Focused on bulk solid dosing, the authors illustrate the potential for misinterpretations if these characteristics are ignored in data evaluation. The sums of amplitudes analysis (SAA) is developed, based on discrete Fourier transformations as a novel non-parametric statistical method for description of time series. Subsequently, the authors use the SAA to investigate bulk solid dosing data. In this process, artifications of data of external catch scales, commonly used for the evaluation of bulk solid dosing, are found, and discussed.
| Original language | English |
|---|---|
| Article number | 118003 |
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Powder Technology |
| Volume | 412 |
| DOIs | |
| Publication status | Published - Nov 2022 |
Bibliographical note
Funding Information:Julian Quodbach reports financial support was provided by Bundesministerium für Wirschaft und Energie .
Funding Information:
The authors would like to thank the Bundesministerium für Wirtschaft und Energie, the Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” e.V. (AiF), and the Forschungsvereinigung Arzneimittel-Hersteller e.V . for funding and organizing the project (IGF project nr. 20574 N / 1). The authors would also like to acknowledge Jörg Breitkreutz, Peter Kleinebudde, Valentinë Elezaj and Marcel Kokott for their fruitful comments and words of encouragement and Sabrina Berkenkemper for providing tableting data.
Funding Information:
Julian Quodbach reports financial support was provided by Bundesministerium für Wirschaft und Energie.The authors would like to thank the Bundesministerium für Wirtschaft und Energie, the Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” e.V. (AiF), and the Forschungsvereinigung Arzneimittel-Hersteller e.V. for funding and organizing the project (IGF project nr. 20574 N / 1). The authors would also like to acknowledge Jörg Breitkreutz, Peter Kleinebudde, Valentinë Elezaj and Marcel Kokott for their fruitful comments and words of encouragement and Sabrina Berkenkemper for providing tableting data.
Publisher Copyright:
© 2022 Elsevier B.V.
Funding
Julian Quodbach reports financial support was provided by Bundesministerium für Wirschaft und Energie . The authors would like to thank the Bundesministerium für Wirtschaft und Energie, the Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” e.V. (AiF), and the Forschungsvereinigung Arzneimittel-Hersteller e.V . for funding and organizing the project (IGF project nr. 20574 N / 1). The authors would also like to acknowledge Jörg Breitkreutz, Peter Kleinebudde, Valentinë Elezaj and Marcel Kokott for their fruitful comments and words of encouragement and Sabrina Berkenkemper for providing tableting data. Julian Quodbach reports financial support was provided by Bundesministerium für Wirschaft und Energie.The authors would like to thank the Bundesministerium für Wirtschaft und Energie, the Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” e.V. (AiF), and the Forschungsvereinigung Arzneimittel-Hersteller e.V. for funding and organizing the project (IGF project nr. 20574 N / 1). The authors would also like to acknowledge Jörg Breitkreutz, Peter Kleinebudde, Valentinë Elezaj and Marcel Kokott for their fruitful comments and words of encouragement and Sabrina Berkenkemper for providing tableting data.
Keywords
- Bulk solid dosing
- Continuous manufacturing
- Data analysis
- Fourier transform
- Powder feeding
- Time series