Sub-nanometer measurement of transient structural changes in dye-doped polystyrene microspheres

Pegah Asgari; Itir Bakiş Dogru Yüksel; Gerhard A. Blab; Hans C. Gerritsen; Allard P. Mosk

doi:10.1364/OPTCON.477703

Sub-nanometer measurement of transient structural changes in dye-doped polystyrene microspheres

Pegah Asgari^*, Itir Bakiş Dogru Yüksel, Gerhard A. Blab, Hans C. Gerritsen, Allard P. Mosk

^*Corresponding author for this work

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We present an interferometric spectral-domain optical coherence tomography microscopy setup to detect structural changes using interference of light reflected from different interfaces of the sample. We induce a reproducible nanometer-scale size change in dye-doped 10-µm polystyrene microspheres by the release of Stokes shift energy of dye molecules inside the microspheres, excited by a modulated 532-nm laser. The resulting optical path length difference was measured with a sensitivity of 0.4 pm/√Hz limited by photodetection noise, and reveals elastic as well as inelastic responses, which opens up possibilities for measuring the response of cell-sized biological objects.

Original language	English
Pages (from-to)	259-265
Number of pages	7
Journal	OSA Continuum
Volume	2
Issue number	2
DOIs	https://doi.org/10.1364/OPTCON.477703
Publication status	Published - 15 Feb 2023

Bibliographical note

Publisher Copyright:
© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Neurophotonics program 6NEPH03, Vici 68047618). The authors would like to thank Dave van den Heuvel, Aron Opheij, Dante Killian, and Paul Jurrius for technical support, and Marcel van der Heijden, Arnout Imhof, Dries van Oosten and Tayebeh Saghaei for discussions.

Funders	Funder number
Arnout Imhof
Marcel van der Heijden
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	6NEPH03, 68047618

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10.1364/OPTCON.477703

optcon-2-2-259Final published version, 2.55 MB

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abstract = "We present an interferometric spectral-domain optical coherence tomography microscopy setup to detect structural changes using interference of light reflected from different interfaces of the sample. We induce a reproducible nanometer-scale size change in dye-doped 10-µm polystyrene microspheres by the release of Stokes shift energy of dye molecules inside the microspheres, excited by a modulated 532-nm laser. The resulting optical path length difference was measured with a sensitivity of 0.4 pm/√Hz limited by photodetection noise, and reveals elastic as well as inelastic responses, which opens up possibilities for measuring the response of cell-sized biological objects.",

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AU - Mosk, Allard P.

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Sub-nanometer measurement of transient structural changes in dye-doped polystyrene microspheres

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