Structure-based design of epitope mimetics

E. E. Moret*, R. M J Liskamp, J. P. Tollenaere

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


The challenge for medicinal chemistry to develop therapeutics for infections and chronic diseases is best met by aiding our immune response. Correct recognition of and adequate response to stimuli depends on B and T cell peptide epitopes. The effectiveness of designing new ligands mimicking bioactive peptides, but with enhanced metabolic stability, has become evident with the arrival of peptidomimetic research. To efficiently design peptidomimetics without affinity-loss, however, a detailed understanding of both the peptide's as well as the mimetics active site is of crucial importance.

Original languageEnglish
Title of host publicationPharmacochemistry Library
Subtitle of host publicationProceedings XIVth International Symposium on Medicinal Chemistry
Number of pages11
Publication statusPublished - 1 Dec 1997

Publication series

NamePharmacochemistry Library
ISSN (Print)0165-7208


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