TY - GEN
T1 - Structure-based design of epitope mimetics
AU - Moret, E. E.
AU - Liskamp, R. M J
AU - Tollenaere, J. P.
PY - 1997/12/1
Y1 - 1997/12/1
N2 - The challenge for medicinal chemistry to develop therapeutics for infections and chronic diseases is best met by aiding our immune response. Correct recognition of and adequate response to stimuli depends on B and T cell peptide epitopes. The effectiveness of designing new ligands mimicking bioactive peptides, but with enhanced metabolic stability, has become evident with the arrival of peptidomimetic research. To efficiently design peptidomimetics without affinity-loss, however, a detailed understanding of both the peptide's as well as the mimetics active site is of crucial importance.
AB - The challenge for medicinal chemistry to develop therapeutics for infections and chronic diseases is best met by aiding our immune response. Correct recognition of and adequate response to stimuli depends on B and T cell peptide epitopes. The effectiveness of designing new ligands mimicking bioactive peptides, but with enhanced metabolic stability, has become evident with the arrival of peptidomimetic research. To efficiently design peptidomimetics without affinity-loss, however, a detailed understanding of both the peptide's as well as the mimetics active site is of crucial importance.
UR - http://www.scopus.com/inward/record.url?scp=77957067301&partnerID=8YFLogxK
U2 - 10.1016/S0165-7208(97)80079-7
DO - 10.1016/S0165-7208(97)80079-7
M3 - Conference contribution
AN - SCOPUS:77957067301
VL - 28
T3 - Pharmacochemistry Library
SP - 371
EP - 381
BT - Pharmacochemistry Library
ER -