Abstract
The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity. STRING is available at http://www.bork.embl-heidelberg.de/STRING.
| Original language | English |
|---|---|
| Pages (from-to) | 3442-3444 |
| Number of pages | 3 |
| Journal | Nucleic Acids Research |
| Volume | 28 |
| Issue number | 18 |
| Publication status | Published - 15 Sept 2000 |
Keywords
- RNA methyltransferase
- article
- computer system
- gene sequence
- Internet
- methodology
- operon
- priority journal
- protein interaction