Strategies to target drugs to gliomas and CNS metastases of solid tumors

B. Milojkovic Kerklaan; O. van Tellingen; A. D R Huitema; J. H. Beijnen; W. Boogerd; J. H M Schellens; D. Brandsma

doi:10.1007/s00415-015-7919-9

Strategies to target drugs to gliomas and CNS metastases of solid tumors

B. Milojkovic Kerklaan, O. van Tellingen, A. D R Huitema, J. H. Beijnen, W. Boogerd, J. H M Schellens, D. Brandsma^*

^*Corresponding author for this work

Pharmacoepidemiology and Clinical Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

Original language	English
Pages (from-to)	428–440
Number of pages	13
Journal	Journal of Neurology
Volume	263
Issue number	3
DOIs	https://doi.org/10.1007/s00415-015-7919-9
Publication status	Published - Mar 2016

Keywords

Antibodies
Brain metastases
Glioma
Nanoparticles
Polymer-based nanocarriers
siRNA

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10.1007/s00415-015-7919-9

StrategiesFinal published version, 730 KBLicence: Taverne

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title = "Strategies to target drugs to gliomas and CNS metastases of solid tumors",

abstract = "The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.",

keywords = "Antibodies, Brain metastases, Glioma, Nanoparticles, Polymer-based nanocarriers, siRNA",

author = "{Milojkovic Kerklaan}, B. and {van Tellingen}, O. and Huitema, {A. D R} and Beijnen, {J. H.} and W. Boogerd and Schellens, {J. H M} and D. Brandsma",

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AU - Milojkovic Kerklaan, B.

AU - van Tellingen, O.

AU - Huitema, A. D R

AU - Beijnen, J. H.

AU - Boogerd, W.

AU - Schellens, J. H M

AU - Brandsma, D.

PY - 2016/3

Y1 - 2016/3

N2 - The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

AB - The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.

KW - Antibodies

KW - Brain metastases

KW - Glioma

KW - Nanoparticles

KW - Polymer-based nanocarriers

KW - siRNA

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SP - 428

EP - 440

JO - Journal of Neurology

JF - Journal of Neurology

IS - 3

ER -

Strategies to target drugs to gliomas and CNS metastases of solid tumors

Abstract

Keywords

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