Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow

Myriam Neumann; Greta di Marco; Dmitrii Iudin; Martina Viola; Cornelus F. van Nostrum; Bas G.P. van Ravensteijn; Tina Vermonden

doi:10.1021/acs.macromol.3c00967

Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow

Myriam Neumann^*
, Greta di Marco
, Dmitrii Iudin
, Martina Viola
, Cornelus F. van Nostrum
, Bas G.P. van Ravensteijn
, Tina Vermonden^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as they allow the biofabrication of complex microstructures. This perspective discusses recent cutting-edge advances as well as current challenges in the field of smart biomaterials for tissue engineering. Additionally, emerging trends and potential future directions are addressed.

Original language	English
Pages (from-to)	8377-8392
Number of pages	16
Journal	Macromolecules
Volume	56
Issue number	21
DOIs	https://doi.org/10.1021/acs.macromol.3c00967
Publication status	Published - 18 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society

Funding

The Dutch Research Council (NWO/VICI 18673) is acknowledged for funding.

Funders	Funder number
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	NWO/VICI 18673

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Cite this

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title = "Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow",

abstract = "In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as they allow the biofabrication of complex microstructures. This perspective discusses recent cutting-edge advances as well as current challenges in the field of smart biomaterials for tissue engineering. Additionally, emerging trends and potential future directions are addressed.",

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doi = "10.1021/acs.macromol.3c00967",

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AU - Neumann, Myriam

AU - di Marco, Greta

AU - Iudin, Dmitrii

AU - Viola, Martina

AU - van Nostrum, Cornelus F.

AU - van Ravensteijn, Bas G.P.

AU - Vermonden, Tina

PY - 2023/10/18

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AB - In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as they allow the biofabrication of complex microstructures. This perspective discusses recent cutting-edge advances as well as current challenges in the field of smart biomaterials for tissue engineering. Additionally, emerging trends and potential future directions are addressed.

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Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow

Abstract

Bibliographical note

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