TY - JOUR
T1 - Stimuli-Responsive Hydrogels
T2 - The Dynamic Smart Biomaterials of Tomorrow
AU - Neumann, Myriam
AU - di Marco, Greta
AU - Iudin, Dmitrii
AU - Viola, Martina
AU - van Nostrum, Cornelus F.
AU - van Ravensteijn, Bas G.P.
AU - Vermonden, Tina
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society
PY - 2023/10/18
Y1 - 2023/10/18
N2 - In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as they allow the biofabrication of complex microstructures. This perspective discusses recent cutting-edge advances as well as current challenges in the field of smart biomaterials for tissue engineering. Additionally, emerging trends and potential future directions are addressed.
AB - In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as they allow the biofabrication of complex microstructures. This perspective discusses recent cutting-edge advances as well as current challenges in the field of smart biomaterials for tissue engineering. Additionally, emerging trends and potential future directions are addressed.
UR - http://www.scopus.com/inward/record.url?scp=85177034197&partnerID=8YFLogxK
U2 - 10.1021/acs.macromol.3c00967
DO - 10.1021/acs.macromol.3c00967
M3 - Review article
C2 - 38024154
AN - SCOPUS:85177034197
SN - 0024-9297
VL - 56
SP - 8377
EP - 8392
JO - Macromolecules
JF - Macromolecules
IS - 21
ER -