Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

S D Kotsakis; L S Tzouvelekis; L Zerva; A Liakopoulos; E Petinaki

doi:10.1007/s10096-011-1289-8

Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

S D Kotsakis, L S Tzouvelekis, L Zerva, A Liakopoulos, E Petinaki^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	31
Issue number	2
DOIs	https://doi.org/10.1007/s10096-011-1289-8
Publication status	Published - Feb 2012
Externally published	Yes

Keywords

Aged, 80 and over
Anti-Bacterial Agents/pharmacology
Endocarditis, Bacterial/microbiology
Female
Humans
Microbial Sensitivity Tests
Models, Molecular
Penicillin-Binding Proteins/chemistry
Peptidyl Transferases/chemistry
Staphylococcal Infections/microbiology
Staphylococcus lugdunensis/drug effects
beta-Lactam Resistance/genetics
beta-Lactams/pharmacology

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10.1007/s10096-011-1289-8

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title = "Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams",

abstract = "We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.",

keywords = "Aged, 80 and over, Anti-Bacterial Agents/pharmacology, Endocarditis, Bacterial/microbiology, Female, Humans, Microbial Sensitivity Tests, Models, Molecular, Penicillin-Binding Proteins/chemistry, Peptidyl Transferases/chemistry, Staphylococcal Infections/microbiology, Staphylococcus lugdunensis/drug effects, beta-Lactam Resistance/genetics, beta-Lactams/pharmacology",

author = "Kotsakis, \{S D\} and Tzouvelekis, \{L S\} and L Zerva and A Liakopoulos and E Petinaki",

year = "2012",

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doi = "10.1007/s10096-011-1289-8",

language = "English",

volume = "31",

pages = "169--172",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

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T1 - Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

AU - Kotsakis, S D

AU - Tzouvelekis, L S

AU - Zerva, L

AU - Liakopoulos, A

AU - Petinaki, E

PY - 2012/2

Y1 - 2012/2

N2 - We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.

AB - We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.

KW - Aged, 80 and over

KW - Anti-Bacterial Agents/pharmacology

KW - Endocarditis, Bacterial/microbiology

KW - Female

KW - Humans

KW - Microbial Sensitivity Tests

KW - Models, Molecular

KW - Penicillin-Binding Proteins/chemistry

KW - Peptidyl Transferases/chemistry

KW - Staphylococcal Infections/microbiology

KW - Staphylococcus lugdunensis/drug effects

KW - beta-Lactam Resistance/genetics

KW - beta-Lactams/pharmacology

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DO - 10.1007/s10096-011-1289-8

M3 - Article

C2 - 21594555

SN - 0934-9723

VL - 31

SP - 169

EP - 172

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

IS - 2

ER -

Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

Abstract

Keywords

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