Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital

Maria Koutsogiannou, Eleanna Drougka, Apostolos Liakopoulos, Eleni Jelastopulu, Efthimia Petinaki, Evangelos D Anastassiou, Iris Spiliopoulou, Myrto Christofidou*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.

Original languageEnglish
Pages (from-to)665-8
Number of pages4
JournalJournal of Clinical Microbiology
Issue number2
Publication statusPublished - Feb 2013
Externally publishedYes


  • Anti-Bacterial Agents/pharmacology
  • Cluster Analysis
  • Cross Infection/diagnosis
  • Disease Outbreaks
  • Drug Resistance, Multiple, Bacterial/genetics
  • Hospitals, University
  • Humans
  • Intensive Care Units
  • Microbial Sensitivity Tests
  • Molecular Typing
  • Pseudomonas Infections/diagnosis
  • Pseudomonas aeruginosa/classification


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