Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital

Maria Koutsogiannou; Eleanna Drougka; Apostolos Liakopoulos; Eleni Jelastopulu; Efthimia Petinaki; Evangelos D Anastassiou; Iris Spiliopoulou; Myrto Christofidou

doi:10.1128/JCM.03071-12

Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital

Maria Koutsogiannou, Eleanna Drougka, Apostolos Liakopoulos, Eleni Jelastopulu, Efthimia Petinaki, Evangelos D Anastassiou, Iris Spiliopoulou, Myrto Christofidou^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.

Original language	English
Pages (from-to)	665-8
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1128/JCM.03071-12
Publication status	Published - Feb 2013
Externally published	Yes

Keywords

Anti-Bacterial Agents/pharmacology
Cluster Analysis
Cross Infection/diagnosis
Disease Outbreaks
Drug Resistance, Multiple, Bacterial/genetics
Hospitals, University
Humans
Intensive Care Units
Microbial Sensitivity Tests
Molecular Typing
Pseudomonas Infections/diagnosis
Pseudomonas aeruginosa/classification

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10.1128/JCM.03071-12

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title = "Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital",

abstract = "An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.",

keywords = "Anti-Bacterial Agents/pharmacology, Cluster Analysis, Cross Infection/diagnosis, Disease Outbreaks, Drug Resistance, Multiple, Bacterial/genetics, Hospitals, University, Humans, Intensive Care Units, Microbial Sensitivity Tests, Molecular Typing, Pseudomonas Infections/diagnosis, Pseudomonas aeruginosa/classification",

author = "Maria Koutsogiannou and Eleanna Drougka and Apostolos Liakopoulos and Eleni Jelastopulu and Efthimia Petinaki and Anastassiou, {Evangelos D} and Iris Spiliopoulou and Myrto Christofidou",

year = "2013",

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doi = "10.1128/JCM.03071-12",

language = "English",

volume = "51",

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AU - Koutsogiannou, Maria

AU - Drougka, Eleanna

AU - Liakopoulos, Apostolos

AU - Jelastopulu, Eleni

AU - Petinaki, Efthimia

AU - Anastassiou, Evangelos D

AU - Spiliopoulou, Iris

AU - Christofidou, Myrto

PY - 2013/2

Y1 - 2013/2

N2 - An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.

AB - An outbreak of multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections in a university hospital is described. Phenotypic and genotypic analysis of 240 isolates revealed that 152 patients, mainly in the intensive care unit (ICU), were colonized or infected with MDRPA, the majority with O11. All metallo-β-lactamase (MBL)-positive isolates carried the bla(VIM-2) or bla(VIM-1) gene. One or more type III secretion system toxin genes were detected in most isolates. Five dominant pulsed-field gel electrophoresis (PFGE) types were characterized, associated with ST235, ST111, ST253, ST309, and ST639.

KW - Anti-Bacterial Agents/pharmacology

KW - Cluster Analysis

KW - Cross Infection/diagnosis

KW - Disease Outbreaks

KW - Drug Resistance, Multiple, Bacterial/genetics

KW - Hospitals, University

KW - Humans

KW - Intensive Care Units

KW - Microbial Sensitivity Tests

KW - Molecular Typing

KW - Pseudomonas Infections/diagnosis

KW - Pseudomonas aeruginosa/classification

U2 - 10.1128/JCM.03071-12

DO - 10.1128/JCM.03071-12

M3 - Article

C2 - 23241381

SN - 0095-1137

VL - 51

SP - 665

EP - 668

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 2

ER -

Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital

Abstract

Keywords

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