Abstract
The site specific attachment of the reactive TMTHSI-click handle to the N-terminus of peptides and proteins is described. The resulting molecular constructs can be used in strain-promoted azide alkyne cycloaddition (SPAAC) for reaction with azide containing proteins e.g., antibodies, peptides, nanoparticles, fluorescent dyes, chelators for radioactive isotopes and SPR-chips etc.
Original language | English |
---|---|
Pages (from-to) | 11397-11400 |
Number of pages | 4 |
Journal | Chemical communications (Cambridge, England) |
Volume | 59 |
Issue number | 76 |
DOIs | |
Publication status | Published - 28 Sept 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Royal Society of Chemistry.
Keywords
- Azides
- Cycloaddition Reaction
- Peptides
- Antibodies
- Alkynes