Specific IgE to individual allergen components: Peanut

Anna M. Ehlers; Edward F. Knol; Stef J. Koppelman

doi:10.1016/B978-0-323-96018-2.00104-8

Specific IgE to individual allergen components: Peanut

Anna M. Ehlers^*
, Edward F. Knol
, Stef J. Koppelman

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The measurement of IgE to peanut extract has been incorporated into the diagnosis of peanut allergy since the 1970s. After Western-blotting provided insight in the relevance of specific allergens present in crude peanut extract, the role of individual allergenic protein became clear. Despite the identification of 17 different peanut allergen components, research has focused on the roles of Ara h 1, 2, 3, 6, 8, and 9. Not only in peanut allergies as such, but also during allergen immunotherapy it was shown that IgE to Ara h 2 and 6 had a high predictive value for clinically relevant peanut allergy.

Original language	English
Title of host publication	Encyclopedia of Food Allergy
Publisher	Elsevier
Pages	V2:495-V2:506
ISBN (Electronic)	9780323960199
ISBN (Print)	9780323960182
DOIs	https://doi.org/10.1016/B978-0-323-96018-2.00104-8
Publication status	Published - 1 Jan 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Keywords

Allergen immunotherapy
Allergy diagnostics
Ara h 2
Ara h 6
Component resolved diagnosis
Epitopes
Peanut
Prevention
Severity prediction
sIgE
sIgG4

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10.1016/B978-0-323-96018-2.00104-8

Cite this

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abstract = "The measurement of IgE to peanut extract has been incorporated into the diagnosis of peanut allergy since the 1970s. After Western-blotting provided insight in the relevance of specific allergens present in crude peanut extract, the role of individual allergenic protein became clear. Despite the identification of 17 different peanut allergen components, research has focused on the roles of Ara h 1, 2, 3, 6, 8, and 9. Not only in peanut allergies as such, but also during allergen immunotherapy it was shown that IgE to Ara h 2 and 6 had a high predictive value for clinically relevant peanut allergy.",

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AB - The measurement of IgE to peanut extract has been incorporated into the diagnosis of peanut allergy since the 1970s. After Western-blotting provided insight in the relevance of specific allergens present in crude peanut extract, the role of individual allergenic protein became clear. Despite the identification of 17 different peanut allergen components, research has focused on the roles of Ara h 1, 2, 3, 6, 8, and 9. Not only in peanut allergies as such, but also during allergen immunotherapy it was shown that IgE to Ara h 2 and 6 had a high predictive value for clinically relevant peanut allergy.

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KW - Allergy diagnostics

KW - Ara h 2

KW - Ara h 6

KW - Component resolved diagnosis

KW - Epitopes

KW - Peanut

KW - Prevention

KW - Severity prediction

KW - sIgE

KW - sIgG4

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SN - 9780323960182

SP - V2:495-V2:506

BT - Encyclopedia of Food Allergy

PB - Elsevier

ER -

Specific IgE to individual allergen components: Peanut

Abstract

Bibliographical note

Keywords

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