Sorting out Sortilins: structural studies on the VPS10 family

N.O.L. Leloup

Sorting out Sortilins: structural studies on the VPS10 family

N.O.L. Leloup

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

The topic of this dissertation is the structural characterization of the VPS10 receptors Sortilin and SorCS2, as well as their interactions with proneurotrophins. A multidisciplinary approach is used to better understand how these receptors function, from ligand binding and release to receptor recycling and signal transduction.

Original language	English
Awarding Institution	Utrecht University
Supervisors/Advisors	Gros, Piet, Primary supervisor Janssen, Bert, Co-supervisor
Award date	10 Nov 2017
Publisher	Utrecht University
Print ISBNs	978-94-6295-776-3
Publication status	Published - 10 Nov 2017

Keywords

Sorting
Receptors
Structures
VPS10
Sortilin
SorCS2

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abstract = "The topic of this dissertation is the structural characterization of the VPS10 receptors Sortilin and SorCS2, as well as their interactions with proneurotrophins. A multidisciplinary approach is used to better understand how these receptors function, from ligand binding and release to receptor recycling and signal transduction.",

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AU - Leloup, N.O.L.

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AB - The topic of this dissertation is the structural characterization of the VPS10 receptors Sortilin and SorCS2, as well as their interactions with proneurotrophins. A multidisciplinary approach is used to better understand how these receptors function, from ligand binding and release to receptor recycling and signal transduction.

KW - Sorting

KW - Receptors

KW - Structures

KW - VPS10

KW - Sortilin

KW - SorCS2

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-94-6295-776-3

PB - Utrecht University

ER -

Sorting out Sortilins: structural studies on the VPS10 family

Abstract

Keywords

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