Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Joanna Lipka; Casper C Hoogenraad

doi:10.1016/j.neuron.2019.10.021

Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Joanna Lipka, Casper C Hoogenraad

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

Original language	English
Pages (from-to)	429-430
Number of pages	2
Journal	Neuron
Volume	104
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2019.10.021
Publication status	Published - 6 Nov 2019
Externally published	Yes

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10.1016/j.neuron.2019.10.021

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title = "Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity",

abstract = "Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.",

author = "Joanna Lipka and Hoogenraad, {Casper C}",

year = "2019",

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AB - Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

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DO - 10.1016/j.neuron.2019.10.021

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SP - 429

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JO - Neuron

JF - Neuron

IS - 3

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Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Abstract

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