Single Synapse LTP: A Matter of Context?

Dennis L H Kruijssen; Corette J Wierenga

doi:10.3389/fncel.2019.00496

Single Synapse LTP: A Matter of Context?

Dennis L H Kruijssen, Corette J Wierenga

Research output: Contribution to journal › Review article › peer-review

Abstract

The most commonly studied form of synaptic plasticity is long-term potentiation (LTP). Over the last 15 years, it has been possible to induce structural and functional LTP in dendritic spines using two-photon glutamate uncaging, allowing for studying the signaling mechanisms of LTP with single synapse resolution. In this review, we compare different stimulation methods to induce single synapse LTP and discuss how LTP is expressed. We summarize the underlying signaling mechanisms that have been studied with high spatiotemporal resolution. Finally, we discuss how LTP in a single synapse can be affected by excitatory and inhibitory synapses nearby. We argue that single synapse LTP is highly dependent on context: the choice of induction method, the history of the dendritic spine and the dendritic vicinity crucially affect signaling pathways and expression of single synapse LTP.

Original language	English
Article number	496
Number of pages	16
Journal	Frontiers in Cellular Neuroscience
Volume	13
DOIs	https://doi.org/10.3389/fncel.2019.00496
Publication status	Published - 2019

Keywords

synaptic plasticity
long-term potentiation
dendritic spine
glutamate uncaging
molecular pathways
synaptic crosstalk

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@article{9a79eca8db25467e90242f05ece0e3be,

title = "Single Synapse LTP: A Matter of Context?",

abstract = "The most commonly studied form of synaptic plasticity is long-term potentiation (LTP). Over the last 15 years, it has been possible to induce structural and functional LTP in dendritic spines using two-photon glutamate uncaging, allowing for studying the signaling mechanisms of LTP with single synapse resolution. In this review, we compare different stimulation methods to induce single synapse LTP and discuss how LTP is expressed. We summarize the underlying signaling mechanisms that have been studied with high spatiotemporal resolution. Finally, we discuss how LTP in a single synapse can be affected by excitatory and inhibitory synapses nearby. We argue that single synapse LTP is highly dependent on context: the choice of induction method, the history of the dendritic spine and the dendritic vicinity crucially affect signaling pathways and expression of single synapse LTP.",

keywords = "synaptic plasticity, long-term potentiation, dendritic spine, glutamate uncaging, molecular pathways, synaptic crosstalk",

author = "Kruijssen, {Dennis L H} and Wierenga, {Corette J}",

note = "Copyright {\textcopyright} 2019 Kruijssen and Wierenga.",

year = "2019",

doi = "10.3389/fncel.2019.00496",

language = "English",

volume = "13",

journal = "Frontiers in Cellular Neuroscience",

issn = "1662-5102",

publisher = "Frontiers Media SA",

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TY - JOUR

T1 - Single Synapse LTP

T2 - A Matter of Context?

AU - Kruijssen, Dennis L H

AU - Wierenga, Corette J

PY - 2019

Y1 - 2019

N2 - The most commonly studied form of synaptic plasticity is long-term potentiation (LTP). Over the last 15 years, it has been possible to induce structural and functional LTP in dendritic spines using two-photon glutamate uncaging, allowing for studying the signaling mechanisms of LTP with single synapse resolution. In this review, we compare different stimulation methods to induce single synapse LTP and discuss how LTP is expressed. We summarize the underlying signaling mechanisms that have been studied with high spatiotemporal resolution. Finally, we discuss how LTP in a single synapse can be affected by excitatory and inhibitory synapses nearby. We argue that single synapse LTP is highly dependent on context: the choice of induction method, the history of the dendritic spine and the dendritic vicinity crucially affect signaling pathways and expression of single synapse LTP.

AB - The most commonly studied form of synaptic plasticity is long-term potentiation (LTP). Over the last 15 years, it has been possible to induce structural and functional LTP in dendritic spines using two-photon glutamate uncaging, allowing for studying the signaling mechanisms of LTP with single synapse resolution. In this review, we compare different stimulation methods to induce single synapse LTP and discuss how LTP is expressed. We summarize the underlying signaling mechanisms that have been studied with high spatiotemporal resolution. Finally, we discuss how LTP in a single synapse can be affected by excitatory and inhibitory synapses nearby. We argue that single synapse LTP is highly dependent on context: the choice of induction method, the history of the dendritic spine and the dendritic vicinity crucially affect signaling pathways and expression of single synapse LTP.

KW - synaptic plasticity

KW - long-term potentiation

KW - dendritic spine

KW - glutamate uncaging

KW - molecular pathways

KW - synaptic crosstalk

U2 - 10.3389/fncel.2019.00496

DO - 10.3389/fncel.2019.00496

M3 - Review article

C2 - 31780899

SN - 1662-5102

VL - 13

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

M1 - 496

ER -

Single Synapse LTP: A Matter of Context?

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