Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-/- mice.

S.R.B.M. Eussen; C.J.M. Rompelberg; K.E. Andersson; O.H. Klungel; P. Hellstrand; R. Oste; H. van Kranen; J. Garssen

Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-/- mice.

S.R.B.M. Eussen, C.J.M. Rompelberg, K.E. Andersson, O.H. Klungel, P. Hellstrand, R. Oste, H. van Kranen, J. Garssen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n=15 per group) for 16 weeks. Both ATO and oat bran were effective in reducing serum total cholesterol levels (low ATO: -5.48, high ATO: -9.12, oat bran: -3.82mmol/l, compared to control (no ATO/no oat bran), all p

Original language	Undefined/Unknown
Pages (from-to)	36-43
Number of pages	8
Journal	Pharmacological Research
Volume	64
Issue number	1
Publication status	Published - 2011

Keywords

Farmacie/Biofarmaceutische wetenschappen (FARM)
Epidemiology
Farmacie(FARM)
Biomedische technologie en medicijnen
Ziekenhuisstructuur en organisatie van de gezondheidszorg
Immunology
Public Health
Pharmacology
Overig medisch onderzoek

Cite this

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title = "Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-/- mice.",

abstract = "The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n=15 per group) for 16 weeks. Both ATO and oat bran were effective in reducing serum total cholesterol levels (low ATO: -5.48, high ATO: -9.12, oat bran: -3.82mmol/l, compared to control (no ATO/no oat bran), all p",

keywords = "Farmacie/Biofarmaceutische wetenschappen (FARM), Epidemiology, Farmacie(FARM), Biomedische technologie en medicijnen, Ziekenhuisstructuur en organisatie van de gezondheidszorg, Immunology, Public Health, Pharmacology, Overig medisch onderzoek",

author = "S.R.B.M. Eussen and C.J.M. Rompelberg and K.E. Andersson and O.H. Klungel and P. Hellstrand and R. Oste and {van Kranen}, H. and J. Garssen",

year = "2011",

language = "Undefined/Unknown",

volume = "64",

pages = "36--43",

journal = "Pharmacological Research",

issn = "1043-6618",

publisher = "Academic Press",

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TY - JOUR

T1 - Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-/- mice.

AU - Eussen, S.R.B.M.

AU - Rompelberg, C.J.M.

AU - Andersson, K.E.

AU - Klungel, O.H.

AU - Hellstrand, P.

AU - Oste, R.

AU - van Kranen, H.

AU - Garssen, J.

PY - 2011

Y1 - 2011

N2 - The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n=15 per group) for 16 weeks. Both ATO and oat bran were effective in reducing serum total cholesterol levels (low ATO: -5.48, high ATO: -9.12, oat bran: -3.82mmol/l, compared to control (no ATO/no oat bran), all p

AB - The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n=15 per group) for 16 weeks. Both ATO and oat bran were effective in reducing serum total cholesterol levels (low ATO: -5.48, high ATO: -9.12, oat bran: -3.82mmol/l, compared to control (no ATO/no oat bran), all p

KW - Farmacie/Biofarmaceutische wetenschappen (FARM)

KW - Epidemiology

KW - Farmacie(FARM)

KW - Biomedische technologie en medicijnen

KW - Ziekenhuisstructuur en organisatie van de gezondheidszorg

KW - Immunology

KW - Public Health

KW - Pharmacology

KW - Overig medisch onderzoek

M3 - Article

SN - 1043-6618

VL - 64

SP - 36

EP - 43

JO - Pharmacological Research

JF - Pharmacological Research

IS - 1

ER -