Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula

Margriet Van Stuijvenberg; José Stam; Christoph Grüber; Fabio Mosca; Sertac Arslanoglu; Gaetano Chirico; Christian P. Braegger; Josef Riedler; Günther Boehm; Pieter J J Sauer; Caroline Van Der Schaaf; Ulrich Wahn; Juliane Wauer; Kirn Parasher; Madeleine Wust; Ingrid Lawnitzak; Marion Trentmann; Gabi Schulz; Eckard Hamelmann; Susanne Paschke-Goossens; Johanna Bellach; Birgit Ahrens; Paola Roggero; Pasqua Piemontese; Maria Lorella Gianni; Laura Morlacchi; Guido Moro; Silvia Rizzardi; Elisa Rigotti; Laura Tandoi; Michela Coppola; Patrick Bühr; Michael Friedt; Rebecca Koller; Daniela Rogler; Vanessa Rueger; Margret Macheiner; Christine Tyma; Gasparoni Antonella; Garzoli Elena; Offer Chiara; Spinoni Vania; Iacono Graziella; Stellini Maria; Jan Van Der Mooren; Yalcin Yavuz; Johan Garssen; Leon Knippels; Jan Knol; Kaouther Ben Amor; Jürgen Jelinek; Bernd Stahl; Esther König; Anja Frings; Anja Wittke; Yvonne Zens; Stephanie Cremers; Kathrin Friedrichs; Janine Gerloff; Gemma Bruno; Ayako Fischer

doi:10.1371/journal.pone.0129927

Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula

Margriet Van Stuijvenberg, José Stam, Christoph Grüber, Fabio Mosca, Sertac Arslanoglu, Gaetano Chirico, Christian P. Braegger, Josef Riedler, Günther Boehm, Pieter J J Sauer, Caroline Van Der Schaaf, Ulrich Wahn, Juliane Wauer, Kirn Parasher, Madeleine Wust, Ingrid Lawnitzak, Marion Trentmann, Gabi Schulz, Eckard Hamelmann, Susanne Paschke-GoossensJohanna Bellach, Birgit Ahrens, Paola Roggero, Pasqua Piemontese, Maria Lorella Gianni, Laura Morlacchi, Guido Moro, Silvia Rizzardi, Elisa Rigotti, Laura Tandoi, Michela Coppola, Patrick Bühr, Michael Friedt, Rebecca Koller, Daniela Rogler, Vanessa Rueger, Margret Macheiner, Christine Tyma, Gasparoni Antonella, Garzoli Elena, Offer Chiara, Spinoni Vania, Iacono Graziella, Stellini Maria, Jan Van Der Mooren, Yalcin Yavuz, Johan Garssen, Leon Knippels, Jan Knol, Kaouther Ben Amor, Jürgen Jelinek, Bernd Stahl, Esther König, Anja Frings, Anja Wittke, Yvonne Zens, Stephanie Cremers, Kathrin Friedrichs, Janine Gerloff, Gemma Bruno, Ayako Fischer

Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.

Original language	English
Article number	e0129927
Journal	PLoS One
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0129927
Publication status	Published - 15 Jun 2015

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Van Stuijvenberg, M., Stam, J., Grüber, C., Mosca, F., Arslanoglu, S., Chirico, G., Braegger, C. P., Riedler, J., Boehm, G., Sauer, P. J. J., Van Der Schaaf, C., Wahn, U., Wauer, J., Parasher, K., Wust, M., Lawnitzak, I., Trentmann, M., Schulz, G., Hamelmann, E., ... Fischer, A. (2015). Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula. PLoS One, 10(6), Article e0129927. https://doi.org/10.1371/journal.pone.0129927

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title = "Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula",

abstract = "This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.",

author = "{Van Stuijvenberg}, Margriet and Jos{\'e} Stam and Christoph Gr{\"u}ber and Fabio Mosca and Sertac Arslanoglu and Gaetano Chirico and Braegger, {Christian P.} and Josef Riedler and G{\"u}nther Boehm and Sauer, {Pieter J J} and {Van Der Schaaf}, Caroline and Ulrich Wahn and Juliane Wauer and Kirn Parasher and Madeleine Wust and Ingrid Lawnitzak and Marion Trentmann and Gabi Schulz and Eckard Hamelmann and Susanne Paschke-Goossens and Johanna Bellach and Birgit Ahrens and Paola Roggero and Pasqua Piemontese and Gianni, {Maria Lorella} and Laura Morlacchi and Guido Moro and Silvia Rizzardi and Elisa Rigotti and Laura Tandoi and Michela Coppola and Patrick B{\"u}hr and Michael Friedt and Rebecca Koller and Daniela Rogler and Vanessa Rueger and Margret Macheiner and Christine Tyma and Gasparoni Antonella and Garzoli Elena and Offer Chiara and Spinoni Vania and Iacono Graziella and Stellini Maria and {Van Der Mooren}, Jan and Yalcin Yavuz and Johan Garssen and Leon Knippels and Jan Knol and Amor, {Kaouther Ben} and J{\"u}rgen Jelinek and Bernd Stahl and Esther K{\"o}nig and Anja Frings and Anja Wittke and Yvonne Zens and Stephanie Cremers and Kathrin Friedrichs and Janine Gerloff and Gemma Bruno and Ayako Fischer",

year = "2015",

month = jun,

day = "15",

doi = "10.1371/journal.pone.0129927",

language = "English",

volume = "10",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

}

Van Stuijvenberg, M, Stam, J, Grüber, C, Mosca, F, Arslanoglu, S, Chirico, G, Braegger, CP, Riedler, J, Boehm, G, Sauer, PJJ, Van Der Schaaf, C, Wahn, U, Wauer, J, Parasher, K, Wust, M, Lawnitzak, I, Trentmann, M, Schulz, G, Hamelmann, E, Paschke-Goossens, S, Bellach, J, Ahrens, B, Roggero, P, Piemontese, P, Gianni, ML, Morlacchi, L, Moro, G, Rizzardi, S, Rigotti, E, Tandoi, L, Coppola, M, Bühr, P, Friedt, M, Koller, R, Rogler, D, Rueger, V, Macheiner, M, Tyma, C, Antonella, G, Elena, G, Chiara, O, Vania, S, Graziella, I, Maria, S, Van Der Mooren, J, Yavuz, Y, Garssen, J, Knippels, L, Knol, J, Amor, KB, Jelinek, J, Stahl, B, König, E, Frings, A, Wittke, A, Zens, Y, Cremers, S, Friedrichs, K, Gerloff, J, Bruno, G & Fischer, A 2015, 'Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula', PLoS One, vol. 10, no. 6, e0129927. https://doi.org/10.1371/journal.pone.0129927

TY - JOUR

T1 - Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula

AU - Van Stuijvenberg, Margriet

AU - Stam, José

AU - Grüber, Christoph

AU - Mosca, Fabio

AU - Arslanoglu, Sertac

AU - Chirico, Gaetano

AU - Braegger, Christian P.

AU - Riedler, Josef

AU - Boehm, Günther

AU - Sauer, Pieter J J

AU - Van Der Schaaf, Caroline

AU - Wahn, Ulrich

AU - Wauer, Juliane

AU - Parasher, Kirn

AU - Wust, Madeleine

AU - Lawnitzak, Ingrid

AU - Trentmann, Marion

AU - Schulz, Gabi

AU - Hamelmann, Eckard

AU - Paschke-Goossens, Susanne

AU - Bellach, Johanna

AU - Ahrens, Birgit

AU - Roggero, Paola

AU - Piemontese, Pasqua

AU - Gianni, Maria Lorella

AU - Morlacchi, Laura

AU - Moro, Guido

AU - Rizzardi, Silvia

AU - Rigotti, Elisa

AU - Tandoi, Laura

AU - Coppola, Michela

AU - Bühr, Patrick

AU - Friedt, Michael

AU - Koller, Rebecca

AU - Rogler, Daniela

AU - Rueger, Vanessa

AU - Macheiner, Margret

AU - Tyma, Christine

AU - Antonella, Gasparoni

AU - Elena, Garzoli

AU - Chiara, Offer

AU - Vania, Spinoni

AU - Graziella, Iacono

AU - Maria, Stellini

AU - Van Der Mooren, Jan

AU - Yavuz, Yalcin

AU - Garssen, Johan

AU - Knippels, Leon

AU - Knol, Jan

AU - Amor, Kaouther Ben

AU - Jelinek, Jürgen

AU - Stahl, Bernd

AU - König, Esther

AU - Frings, Anja

AU - Wittke, Anja

AU - Zens, Yvonne

AU - Cremers, Stephanie

AU - Friedrichs, Kathrin

AU - Gerloff, Janine

AU - Bruno, Gemma

AU - Fischer, Ayako

PY - 2015/6/15

Y1 - 2015/6/15

N2 - This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.

AB - This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.

UR - http://www.scopus.com/inward/record.url?scp=84953931605&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0129927

DO - 10.1371/journal.pone.0129927

M3 - Article

AN - SCOPUS:84953931605

SN - 1932-6203

VL - 10

JO - PLoS One

JF - PLoS One

IS - 6

M1 - e0129927

ER -

Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula

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