TY - JOUR
T1 - SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides
AU - Patureau, F.W.
AU - Worch, C.
AU - Siegler, M.A.M.
AU - Spek, A.L.
AU - Bolm, C.
AU - Reek, J.N.H.
PY - 2012
Y1 - 2012
N2 - Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P-N-S-N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri- and tetrasubstituted enamides leads to products with high enantioselectivities (up to 92% ee).
AB - Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P-N-S-N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri- and tetrasubstituted enamides leads to products with high enantioselectivities (up to 92% ee).
U2 - 10.1002/adsc.201100692
DO - 10.1002/adsc.201100692
M3 - Article
SN - 1615-4150
VL - 354
SP - 59
EP - 64
JO - Advanced synthesis & catalysis
JF - Advanced synthesis & catalysis
IS - 1
ER -