Short-term efficacy of nicotine replacement therapy for smoking cessation in adolescents: A randomized controlled trial

Charlotte S. Scherphof*, Regina J. J. M. van den Eijnden, Rutger C. M. E. Engels, Wilma A. M. Vollebergh

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The aim of this randomized, double-blind placebo-controlled clinical trial is to test the efficacy and safety of nicotine replacement therapy (NRT) in promoting end-of-treatment abstinence among adolescents and whether this relation is moderated by medication compliance. Participants (N = 257, age: 16.7 +/- 1.13 years) attended an information meeting followed by a 6- or 9-week treatment. Self-reported smoking cessation, compliance, and side effects were measured by means of online questionnaires. Intent-to-treat analyses showed that independent of compliance, NRT is effective in promoting abstinence rates after 2 weeks (OR = 2.02, 95% CI = 1.11-3.69), but not end-of-treatment abstinence. However, end-of-treatment abstinence rates significantly increased in high-compliant (OR = 1.09, 95% CI = 1.01-1.17) and not in low-compliant participants. No serious adverse events were found. Future research is warranted to disentangle the process involving the decrease in abstinence rates and compliance rates from the third week after the quit date onwards. (C) 2013 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalJournal of Substance Abuse Treatment
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Smoking cessation
  • Adolescents
  • Nicotine patch
  • Randomized controlled trial
  • HIGH-SCHOOL-STUDENTS
  • CIGARETTE-SMOKING
  • CLINICAL-TRIAL
  • ADULT SMOKERS
  • UNITED-STATES
  • PATCH
  • QUIT
  • PREDICTORS
  • ADHERENCE
  • METAANALYSIS

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