Severity of experimental Escherichia coli mastitis in ketonemic and nonketonemic dairy cows

W D Kremer, E N Noordhuizen-Stassen, F J Grommers, Y H Schukken, R Heeringa, A Brand, C Burvenich

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The severity of experimental Escherichia coli mastitis in relation to in vitro chemotaxis of polymorphonuclear leukocytes was investigated in cows during negative energy balance. The negative energy balance was induced by feed restriction. Cows were classified into two groups, ketonemic and nonketonemic, based on the beta-hydroxybutyrate concentration in the peripheral blood at the moment of inoculation. Bacterial growth in the inoculated quarter was used as a parameter to indicate the severity of experimental mastitis. In the nonketonemic cows, experimental mastitis ranged from moderate to severe. Severity of experimental mastitis was negatively related to preinfection chemotactic response of polymorphonuclear leukocytes. In contrast, the course of experimental mastitis in the ketonemic group was relatively severe in all cows, regardless of preinfection chemotactic response.

Original languageEnglish
Pages (from-to)3428-36
Number of pages9
JournalJournal of Dairy Science
Volume76
Issue number11
DOIs
Publication statusPublished - Nov 1993

Keywords

  • 3-Hydroxybutyric Acid
  • Animals
  • Blood Glucose/metabolism
  • Cattle
  • Chemotaxis, Leukocyte
  • Disease Susceptibility
  • Energy Metabolism
  • Escherichia coli Infections
  • Female
  • Food Deprivation
  • Hydroxybutyrates/blood
  • Lactation
  • Mastitis, Bovine/blood
  • Neutrophils/physiology

Fingerprint

Dive into the research topics of 'Severity of experimental Escherichia coli mastitis in ketonemic and nonketonemic dairy cows'. Together they form a unique fingerprint.

Cite this