Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

J.G.C. van Hasselt; N.K. van Eijkelenburg; AD Huitema; J.H.M. Schellens; A.Y. Sch outen-van Meeteren

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

J.G.C. van Hasselt, N.K. van Eijkelenburg, AD Huitema, J.H.M. Schellens, A.Y. Sch outen-van Meeteren

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Abstract

We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.

Original language	Undefined/Unknown
Pages (from-to)	2878-81
Number of pages	4
Journal	Antimicrob Agents Chemother
Volume	57
Issue number	6
Publication status	Published - 2013

Cite this

@article{d6fff56317c84e6d989c2308457ba781,

title = "Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.",

abstract = "We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.",

author = "{van Hasselt}, J.G.C. and {van Eijkelenburg}, N.K. and AD Huitema and J.H.M. Schellens and {Sch outen-van Meeteren}, A.Y.",

year = "2013",

language = "Undefined/Unknown",

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pages = "2878--81",

journal = "Antimicrob Agents Chemother",

issn = "1098-6596",

publisher = "American Society for Microbiology",

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T1 - Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

AU - van Hasselt, J.G.C.

AU - van Eijkelenburg, N.K.

AU - Huitema, AD

AU - Schellens, J.H.M.

AU - Sch outen-van Meeteren, A.Y.

PY - 2013

Y1 - 2013

N2 - We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.

AB - We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.

M3 - Article

SN - 1098-6596

VL - 57

SP - 2878

EP - 2881

JO - Antimicrob Agents Chemother

JF - Antimicrob Agents Chemother

IS - 6

ER -