Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study

Saskia M Willers; Bert Brunekreef; Marieke Abrahamse-Berkeveld; Bert van de Heijning; Eline van der Beek; Dirkje S Postma; Marjan Kerkhof; Henriëtte A Smit; Alet H Wijga

doi:10.1159/000369979

Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study

Saskia M Willers, Bert Brunekreef, Marieke Abrahamse-Berkeveld, Bert van de Heijning, Eline van der Beek, Dirkje S Postma, Marjan Kerkhof, Henriëtte A Smit, Alet H Wijga

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND/AIMS: Visfatin has been suggested as a marker of visceral adiposity. We hypothesized that visfatin, but not leptin, would be specifically associated with visceral adiposity. We investigated the relation of serum visfatin and leptin with measures of adiposity and body fat distribution in children.

METHODS: Serum leptin and visfatin levels were measured in 1,022 12-year-old children participating in the PIAMA birth cohort. BMI, waist, hip and upper arm circumference were available for all children. Multiple linear regression analyses were conducted to study associations between different anthropometric indices and log serum visfatin and leptin levels.

RESULTS: All anthropometric indices showed positive and strong dose-response relationships with serum leptin. Visfatin was increased only in children with a high waist-to-hip ratio. The effect size was small compared to those observed for leptin and the association was present in overweight children (n = 133) but not in normal weight children.

CONCLUSION: Serum leptin levels strongly increased with increasing adiposity, but were not related to a specific type of fat distribution. In contrast, serum visfatin was associated only with high waist-to-hip ratio in overweight children. Based on our study we would currently not recommend visfatin as a marker of visceral adiposity in the general population of children. © 2015 S. Karger AG, Basel.

Original language	English
Pages (from-to)	63-71
Number of pages	9
Journal	Annals of Nutrition and Metabolism
Volume	66
Issue number	2-3
DOIs	https://doi.org/10.1159/000369979
Publication status	Published - Jun 2015

Keywords

Visfatin
Leptin
Childhood adiposity
Anthropometry

Access to Document

10.1159/000369979

369979Final published version, 543 KBLicence: Taverne

Cite this

@article{4c66b50146bf43899e02d4fc5d5f5d7c,

title = "Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study",

abstract = "BACKGROUND/AIMS: Visfatin has been suggested as a marker of visceral adiposity. We hypothesized that visfatin, but not leptin, would be specifically associated with visceral adiposity. We investigated the relation of serum visfatin and leptin with measures of adiposity and body fat distribution in children.METHODS: Serum leptin and visfatin levels were measured in 1,022 12-year-old children participating in the PIAMA birth cohort. BMI, waist, hip and upper arm circumference were available for all children. Multiple linear regression analyses were conducted to study associations between different anthropometric indices and log serum visfatin and leptin levels.RESULTS: All anthropometric indices showed positive and strong dose-response relationships with serum leptin. Visfatin was increased only in children with a high waist-to-hip ratio. The effect size was small compared to those observed for leptin and the association was present in overweight children (n = 133) but not in normal weight children.CONCLUSION: Serum leptin levels strongly increased with increasing adiposity, but were not related to a specific type of fat distribution. In contrast, serum visfatin was associated only with high waist-to-hip ratio in overweight children. Based on our study we would currently not recommend visfatin as a marker of visceral adiposity in the general population of children. {\textcopyright} 2015 S. Karger AG, Basel.",

keywords = "Visfatin, Leptin, Childhood adiposity, Anthropometry",

author = "Willers, {Saskia M} and Bert Brunekreef and Marieke Abrahamse-Berkeveld and {van de Heijning}, Bert and {van der Beek}, Eline and Postma, {Dirkje S} and Marjan Kerkhof and Smit, {Henri{\"e}tte A} and Wijga, {Alet H}",

year = "2015",

month = jun,

doi = "10.1159/000369979",

language = "English",

volume = "66",

pages = "63--71",

journal = "Annals of Nutrition and Metabolism",

issn = "0250-6807",

publisher = "S. Karger AG",

number = "2-3",

}

TY - JOUR

T1 - Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study

AU - Willers, Saskia M

AU - Brunekreef, Bert

AU - Abrahamse-Berkeveld, Marieke

AU - van de Heijning, Bert

AU - van der Beek, Eline

AU - Postma, Dirkje S

AU - Kerkhof, Marjan

AU - Smit, Henriëtte A

AU - Wijga, Alet H

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND/AIMS: Visfatin has been suggested as a marker of visceral adiposity. We hypothesized that visfatin, but not leptin, would be specifically associated with visceral adiposity. We investigated the relation of serum visfatin and leptin with measures of adiposity and body fat distribution in children.METHODS: Serum leptin and visfatin levels were measured in 1,022 12-year-old children participating in the PIAMA birth cohort. BMI, waist, hip and upper arm circumference were available for all children. Multiple linear regression analyses were conducted to study associations between different anthropometric indices and log serum visfatin and leptin levels.RESULTS: All anthropometric indices showed positive and strong dose-response relationships with serum leptin. Visfatin was increased only in children with a high waist-to-hip ratio. The effect size was small compared to those observed for leptin and the association was present in overweight children (n = 133) but not in normal weight children.CONCLUSION: Serum leptin levels strongly increased with increasing adiposity, but were not related to a specific type of fat distribution. In contrast, serum visfatin was associated only with high waist-to-hip ratio in overweight children. Based on our study we would currently not recommend visfatin as a marker of visceral adiposity in the general population of children. © 2015 S. Karger AG, Basel.

AB - BACKGROUND/AIMS: Visfatin has been suggested as a marker of visceral adiposity. We hypothesized that visfatin, but not leptin, would be specifically associated with visceral adiposity. We investigated the relation of serum visfatin and leptin with measures of adiposity and body fat distribution in children.METHODS: Serum leptin and visfatin levels were measured in 1,022 12-year-old children participating in the PIAMA birth cohort. BMI, waist, hip and upper arm circumference were available for all children. Multiple linear regression analyses were conducted to study associations between different anthropometric indices and log serum visfatin and leptin levels.RESULTS: All anthropometric indices showed positive and strong dose-response relationships with serum leptin. Visfatin was increased only in children with a high waist-to-hip ratio. The effect size was small compared to those observed for leptin and the association was present in overweight children (n = 133) but not in normal weight children.CONCLUSION: Serum leptin levels strongly increased with increasing adiposity, but were not related to a specific type of fat distribution. In contrast, serum visfatin was associated only with high waist-to-hip ratio in overweight children. Based on our study we would currently not recommend visfatin as a marker of visceral adiposity in the general population of children. © 2015 S. Karger AG, Basel.

KW - Visfatin

KW - Leptin

KW - Childhood adiposity

KW - Anthropometry

U2 - 10.1159/000369979

DO - 10.1159/000369979

M3 - Article

C2 - 25612646

SN - 0250-6807

VL - 66

SP - 63

EP - 71

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

IS - 2-3

ER -

Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study

Abstract

Keywords

Access to Document

Fingerprint

Cite this