Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life

Samantha W. J. He, Franziska Voss, Mioara A. Nicolaie, Jolanda Brummelman, Martijn D. B. van de Garde, Elske Bijvank, Martien Poelen, Alienke J. Wijmenga-Monsuur, Anne L. Wyllie, Krzysztof Trzcinski, Josine Van Beek, Nynke Y. Rots, Gerco den Hartog, Sven Hammerschmidt*, Cecile A. C. M. van Els*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Streptococcus pneumoniae is a leading cause of morbidity and mortality in children and older adults. However, knowledge on the development of pneumococcal protein-specific antibody responses throughout life is limited. To investigate this, we measured serum immunoglobulin G (IgG) levels to 55 pneumococcal proteins in 11-month-old infants (n = 73), 24-month-old children (n = 101), parents (n = 99), adults without children <6 years of age (n = 99), and older adults aged >60 years (n = 100). Our findings revealed low IgG levels in infancy, with distinct development patterns peaking in adults. A decrease in levels was observed for 27 antigens towards older age. Adults and older adults had increased IgG levels during pneumococcal carriage and at increased exposure risk to S. pneumoniae. Carriage was a stronger predictor than exposure or age for antibody responses. These findings highlight the dynamic nature of naturally acquired humoral immunity to pneumococcal proteins throughout life, offering insights for age-targeted interventions.
Original languageEnglish
Number of pages12
JournalJournal of Infectious Diseases
DOIs
Publication statusE-pub ahead of print - 29 Apr 2024

Keywords

  • Streptococcus pneumoniae
  • Aging
  • Antibodies
  • Pneumococcal carriage
  • Pneumococcal proteins

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