Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

Markus Weingarth; Yuichi Masuda; K. Takegoshi; Geoffrey Bodenhausen; Piotr Tekely

doi:10.1007/s10858-011-9501-9

Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

Markus Weingarth, Yuichi Masuda, K. Takegoshi, Geoffrey Bodenhausen, Piotr Tekely

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Sensitive 2D solid-state 13C-13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5-4Å . © 2011 Springer Science+Business Media B.V.

Original language	English
Pages (from-to)	129-136
Number of pages	8
Journal	Journal of Biomolecular NMR
Volume	50
Issue number	2
DOIs	https://doi.org/10.1007/s10858-011-9501-9
Publication status	Published - 1 Jun 2011

Keywords

13C-13C 2D correlation spectra
Amyloid β
Dipolar truncation
Fibrils
PARIS-xy dipolar recoupling
Solid-state NMR
Ultra-high magnetic field
amyloid
carbon 13
analytic method
article
electrospinning
magnetic field
nuclear magnetic resonance
paris xy
priority journal

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title = "Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields",

abstract = "Sensitive 2D solid-state 13C-13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5-4{\AA} . {\textcopyright} 2011 Springer Science+Business Media B.V.",

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author = "Markus Weingarth and Yuichi Masuda and K. Takegoshi and Geoffrey Bodenhausen and Piotr Tekely",

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doi = "10.1007/s10858-011-9501-9",

language = "English",

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journal = "Journal of Biomolecular NMR",

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T1 - Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

AU - Weingarth, Markus

AU - Masuda, Yuichi

AU - Takegoshi, K.

AU - Bodenhausen, Geoffrey

AU - Tekely, Piotr

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Sensitive 2D solid-state 13C-13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5-4Å . © 2011 Springer Science+Business Media B.V.

AB - Sensitive 2D solid-state 13C-13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5-4Å . © 2011 Springer Science+Business Media B.V.

KW - 13C-13C 2D correlation spectra

KW - Amyloid β

KW - Dipolar truncation

KW - Fibrils

KW - PARIS-xy dipolar recoupling

KW - Solid-state NMR

KW - Ultra-high magnetic field

KW - amyloid

KW - carbon 13

KW - analytic method

KW - article

KW - electrospinning

KW - magnetic field

KW - nuclear magnetic resonance

KW - paris xy

KW - priority journal

U2 - 10.1007/s10858-011-9501-9

DO - 10.1007/s10858-011-9501-9

M3 - Article

SN - 0925-2738

VL - 50

SP - 129

EP - 136

JO - Journal of Biomolecular NMR

JF - Journal of Biomolecular NMR

IS - 2

ER -

Sensitive 13C-13C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

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Keywords

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