Abstract
Sensitive 2D solid-state 13C-13C correlation spectra of amyloid β fibrils have been recorded at very fast spinning frequencies and very high magnetic fields. It is demonstrated that PARIS-xy recoupling using moderate rf amplitudes can provide structural information by promoting efficient magnetization transfer even under such challenging experimental conditions. Furthermore, it has been shown both experimentally and by numerical simulations that the method is not very sensitive to dipolar truncation effects and can reveal direct transfer across distances of about 3.5-4Å . © 2011 Springer Science+Business Media B.V.
Original language | English |
---|---|
Pages (from-to) | 129-136 |
Number of pages | 8 |
Journal | Journal of Biomolecular NMR |
Volume | 50 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Jun 2011 |
Keywords
- 13C-13C 2D correlation spectra
- Amyloid β
- Dipolar truncation
- Fibrils
- PARIS-xy dipolar recoupling
- Solid-state NMR
- Ultra-high magnetic field
- amyloid
- carbon 13
- analytic method
- article
- electrospinning
- magnetic field
- nuclear magnetic resonance
- paris xy
- priority journal