Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C

R. Ulferts; H.J. Thibaut; K.H.W. Lanke; P. Leyssen; B. Coutard; A.M. De Palma; B. Canard; J. Neyts; F.J.M. van Kuppeveld

doi:10.1128/AAC.02084-12

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C

R. Ulferts, H.J. Thibaut, K.H.W. Lanke, P. Leyssen, B. Coutard, A.M. De Palma, B. Canard, J. Neyts, F.J.M. van Kuppeveld

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.

Original language	Undefined/Unknown
Pages (from-to)	1952-1956
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02084-12
Publication status	Published - 2013

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Ulferts, R., Thibaut, H. J., Lanke, K. H. W., Leyssen, P., Coutard, B., De Palma, A. M., Canard, B., Neyts, J., & van Kuppeveld, F. J. M. (2013). Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C. Antimicrobial Agents and Chemotherapy, 57(4), 1952-1956. https://doi.org/10.1128/AAC.02084-12

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abstract = "Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.",

author = "R. Ulferts and H.J. Thibaut and K.H.W. Lanke and P. Leyssen and B. Coutard and {De Palma}, A.M. and B. Canard and J. Neyts and {van Kuppeveld}, F.J.M.",

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doi = "10.1128/AAC.02084-12",

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AU - Ulferts, R.

AU - Thibaut, H.J.

AU - Lanke, K.H.W.

AU - Leyssen, P.

AU - Coutard, B.

AU - De Palma, A.M.

AU - Canard, B.

AU - Neyts, J.

AU - van Kuppeveld, F.J.M.

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N2 - Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.

AB - Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.

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DO - 10.1128/AAC.02084-12

M3 - Article

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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