Abstract
Transport proteins expressed in liver and kidney have been studied in great detail on the molecular and cellular level, using membrane vesicles and (transport protein transfected) cell lines. Regulation of transport is studied best in cell systems, whereas an accurate determination of overall hepatic or renal drug clearance can be studied in organs. Hence, translation of this information into a physiological and pharmacological context of individual transporters in hepatic and renal drug handling still needs to be addressed adequately.:
| Original language | English |
|---|---|
| Pages (from-to) | 357-64 |
| Number of pages | 8 |
| Journal | Drug Discovery Today. Technologies |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2004 |