Screening for Novel Drug Targets in Cancer

J.H. Nijwening

Research output: ThesisDoctoral thesis 2 (Research NOT UU / Graduation UU)


Most cancer drugs are not specific enough, causing unwanted side effects and recurrence of treated tumors. Some modern cancer drugs, the so-called targeted therapeutics, specifically target tumor cells, while leaving normal and healthy cells unharmed. The aim of the research described in this thesis was to identify novel drug targets for targeted therapeutics. The tool applied to conduct this research was high-throughput RNAi screening. The validated hits of this screening approach might be distinct drug targets that are only toxic within a cancer-specific context.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Utrecht University
  • Bernards, R.A., Primary supervisor, External person
  • Beijersbergen, R.L., Co-supervisor, External person
Award date10 Jan 2012
Print ISBNs978-94-6182-062-4
Publication statusPublished - 10 Jan 2012


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