Schistosoma mansoni: the egg, biosynthesis of the shell and interaction with the host

Saskia deWalick; Aloysius G M Tielens; Jaap J van Hellemond

doi:10.1016/j.exppara.2011.07.018

Schistosoma mansoni: the egg, biosynthesis of the shell and interaction with the host

Saskia deWalick, Aloysius G M Tielens, Jaap J van Hellemond

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The schistosome eggshell is a hardened and tanned structure made from cross-linked proteins. It is synthesized within the female worm from many different kinds of proteins and glycoproteins. Once the egg is released in the circulation, the outer surface of the eggshell is exposed and hence a direct site of interaction between the parasite and the host. The major eggshell protein is p14, but about one third of the eggshell is made from common cellular proteins, some of which are known to be immunogenic. This has many consequences for parasite-host interactions. However, so far, the eggshell has gained little attention from researchers. We will discuss the structure of the eggshell and its role in granuloma formation, host factor binding and egg excretion.

Original language	English
Pages (from-to)	7-13
Number of pages	7
Journal	Experimental Parasitology
Volume	132
Issue number	1
DOIs	https://doi.org/10.1016/j.exppara.2011.07.018
Publication status	Published - Sept 2012

Bibliographical note

Keywords

Amino Acids
Animals
Antigens, Helminth
Female
Granuloma
Helminth Proteins
Host-Parasite Interactions
Ovum
Polysaccharides
Schistosoma mansoni
Schistosomiasis mansoni

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.exppara.2011.07.018

Cite this

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title = "Schistosoma mansoni: the egg, biosynthesis of the shell and interaction with the host",

abstract = "The schistosome eggshell is a hardened and tanned structure made from cross-linked proteins. It is synthesized within the female worm from many different kinds of proteins and glycoproteins. Once the egg is released in the circulation, the outer surface of the eggshell is exposed and hence a direct site of interaction between the parasite and the host. The major eggshell protein is p14, but about one third of the eggshell is made from common cellular proteins, some of which are known to be immunogenic. This has many consequences for parasite-host interactions. However, so far, the eggshell has gained little attention from researchers. We will discuss the structure of the eggshell and its role in granuloma formation, host factor binding and egg excretion.",

keywords = "Amino Acids, Animals, Antigens, Helminth, Female, Granuloma, Helminth Proteins, Host-Parasite Interactions, Ovum, Polysaccharides, Schistosoma mansoni, Schistosomiasis mansoni",

author = "Saskia deWalick and Tielens, {Aloysius G M} and {van Hellemond}, {Jaap J}",

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AU - Tielens, Aloysius G M

AU - van Hellemond, Jaap J

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KW - Amino Acids

KW - Animals

KW - Antigens, Helminth

KW - Female

KW - Granuloma

KW - Helminth Proteins

KW - Host-Parasite Interactions

KW - Ovum

KW - Polysaccharides

KW - Schistosoma mansoni

KW - Schistosomiasis mansoni

U2 - 10.1016/j.exppara.2011.07.018

DO - 10.1016/j.exppara.2011.07.018

M3 - Article

C2 - 21840309

SN - 0014-4894

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SP - 7

EP - 13

JO - Experimental Parasitology

JF - Experimental Parasitology

IS - 1

ER -

Schistosoma mansoni: the egg, biosynthesis of the shell and interaction with the host

Abstract

Bibliographical note

Keywords

UN SDGs

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