Saffold cardiovirus and multiple sclerosis: no evidence for an association

Jochem M D Galama; Jan G Zoll; Kjerstin H Lanke; Arjan S de Jong; Jeroen Melief; Inge Huitinga; Marcel M Verbeek; Frank J M van Kuppeveld

doi:10.1002/acn3.82

Saffold cardiovirus and multiple sclerosis: no evidence for an association

Jochem M D Galama, Jan G Zoll, Kjerstin H Lanke, Arjan S de Jong, Jeroen Melief, Inge Huitinga, Marcel M Verbeek, Frank J M van Kuppeveld

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Saffold cardiovirus, a newly discovered human cardiovirus, has close similarity with Theiler's murine encephalomyelitis virus (TMEV) which can cause a chronic demyelinating encephalomyelitis in mice. In this study, we tested whether Saffold cardiovirus infection of the brain is associated with multiple sclerosis (MS). Autopsy white matter samples from 19 MS and 9 normal brain donors were tested by polymerase chain reaction. All were negative. Paired cerebrospinal fluid and serum samples from 24 MS patients and 27 controls were tested for Saffold cardiovirus-specific oligoclonal bands, two patients and two controls reacted positive. We conclude that an association between Saffold cardiovirus and MS is highly improbable.

Original language	English
Pages (from-to)	618-21
Number of pages	4
Journal	Annals of Clinical and Translational Neurology
Volume	1
Issue number	8
DOIs	https://doi.org/10.1002/acn3.82
Publication status	Published - Aug 2014

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title = "Saffold cardiovirus and multiple sclerosis: no evidence for an association",

abstract = "Saffold cardiovirus, a newly discovered human cardiovirus, has close similarity with Theiler's murine encephalomyelitis virus (TMEV) which can cause a chronic demyelinating encephalomyelitis in mice. In this study, we tested whether Saffold cardiovirus infection of the brain is associated with multiple sclerosis (MS). Autopsy white matter samples from 19 MS and 9 normal brain donors were tested by polymerase chain reaction. All were negative. Paired cerebrospinal fluid and serum samples from 24 MS patients and 27 controls were tested for Saffold cardiovirus-specific oligoclonal bands, two patients and two controls reacted positive. We conclude that an association between Saffold cardiovirus and MS is highly improbable.",

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T2 - no evidence for an association

AU - Galama, Jochem M D

AU - Zoll, Jan G

AU - Lanke, Kjerstin H

AU - de Jong, Arjan S

AU - Melief, Jeroen

AU - Huitinga, Inge

AU - Verbeek, Marcel M

AU - van Kuppeveld, Frank J M

PY - 2014/8

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AB - Saffold cardiovirus, a newly discovered human cardiovirus, has close similarity with Theiler's murine encephalomyelitis virus (TMEV) which can cause a chronic demyelinating encephalomyelitis in mice. In this study, we tested whether Saffold cardiovirus infection of the brain is associated with multiple sclerosis (MS). Autopsy white matter samples from 19 MS and 9 normal brain donors were tested by polymerase chain reaction. All were negative. Paired cerebrospinal fluid and serum samples from 24 MS patients and 27 controls were tested for Saffold cardiovirus-specific oligoclonal bands, two patients and two controls reacted positive. We conclude that an association between Saffold cardiovirus and MS is highly improbable.

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DO - 10.1002/acn3.82

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JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

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Saffold cardiovirus and multiple sclerosis: no evidence for an association

Abstract

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