S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery

J W Wirds; A E J Duyn; S D Geraerts; E Preijer; J A A M Van Diemen-Steenvoorde; J H Schagen Van Leeuwen; F J L M Haas; W B M Gerritsen; A De Boer; J A Leusink

S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery

J W Wirds, A E J Duyn, S D Geraerts, E Preijer, J A A M Van Diemen-Steenvoorde, J H Schagen Van Leeuwen, F J L M Haas, W B M Gerritsen, A De Boer, J A Leusink

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system.

OBJECTIVE: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery.

METHOD: S100 protein levels in umbilical cord blood of 81 healthy infants were determined.

RESULTS: S100 protein was present in arterial (median concentration 1.62 micro g/l) and venous (median concentration 1.36 micro g/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 micro g/l; median venous concentration 1.48 micro g/l) than births by caesarean section (1.51 micro g/l and 1.26 micro g/l respectively).

CONCLUSION: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia.

Original language	English
Pages (from-to)	F67-9
Number of pages	3
Journal	Archives of Disease in Childhood Fetal and Neonatal Edition
Volume	88
Issue number	1
Publication status	Published - Jan 2003

Keywords

Asphyxia Neonatorum
Biological Markers
Cesarean Section
Delivery, Obstetric
Female
Fetal Blood
Humans
Infant, Newborn
Male
S100 Proteins

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Wirds, J. W., Duyn, A. E. J., Geraerts, S. D., Preijer, E., Van Diemen-Steenvoorde, J. A. A. M., Van Leeuwen, J. H. S., Haas, F. J. L. M., Gerritsen, W. B. M., De Boer, A., & Leusink, J. A. (2003). S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery. Archives of Disease in Childhood Fetal and Neonatal Edition, 88(1), F67-9.

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title = "S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery",

abstract = "BACKGROUND: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system.OBJECTIVE: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery.METHOD: S100 protein levels in umbilical cord blood of 81 healthy infants were determined.RESULTS: S100 protein was present in arterial (median concentration 1.62 micro g/l) and venous (median concentration 1.36 micro g/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 micro g/l; median venous concentration 1.48 micro g/l) than births by caesarean section (1.51 micro g/l and 1.26 micro g/l respectively).CONCLUSION: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia.",

keywords = "Asphyxia Neonatorum, Biological Markers, Cesarean Section, Delivery, Obstetric, Female, Fetal Blood, Humans, Infant, Newborn, Male, S100 Proteins",

author = "Wirds, {J W} and Duyn, {A E J} and Geraerts, {S D} and E Preijer and {Van Diemen-Steenvoorde}, {J A A M} and {Van Leeuwen}, {J H Schagen} and Haas, {F J L M} and Gerritsen, {W B M} and {De Boer}, A and Leusink, {J A}",

year = "2003",

month = jan,

language = "English",

volume = "88",

pages = "F67--9",

journal = "Archives of Disease in Childhood Fetal and Neonatal Edition",

issn = "1359-2998",

publisher = "BMJ Publishing Group Ltd",

number = "1",

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TY - JOUR

T1 - S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery

AU - Wirds, J W

AU - Duyn, A E J

AU - Geraerts, S D

AU - Preijer, E

AU - Van Diemen-Steenvoorde, J A A M

AU - Van Leeuwen, J H Schagen

AU - Haas, F J L M

AU - Gerritsen, W B M

AU - De Boer, A

AU - Leusink, J A

PY - 2003/1

Y1 - 2003/1

N2 - BACKGROUND: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system.OBJECTIVE: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery.METHOD: S100 protein levels in umbilical cord blood of 81 healthy infants were determined.RESULTS: S100 protein was present in arterial (median concentration 1.62 micro g/l) and venous (median concentration 1.36 micro g/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 micro g/l; median venous concentration 1.48 micro g/l) than births by caesarean section (1.51 micro g/l and 1.26 micro g/l respectively).CONCLUSION: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia.

AB - BACKGROUND: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system.OBJECTIVE: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery.METHOD: S100 protein levels in umbilical cord blood of 81 healthy infants were determined.RESULTS: S100 protein was present in arterial (median concentration 1.62 micro g/l) and venous (median concentration 1.36 micro g/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 micro g/l; median venous concentration 1.48 micro g/l) than births by caesarean section (1.51 micro g/l and 1.26 micro g/l respectively).CONCLUSION: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia.

KW - Asphyxia Neonatorum

KW - Biological Markers

KW - Cesarean Section

KW - Delivery, Obstetric

KW - Female

KW - Fetal Blood

KW - Humans

KW - Infant, Newborn

KW - Male

KW - S100 Proteins

M3 - Article

C2 - 12496231

SN - 1359-2998

VL - 88

SP - F67-9

JO - Archives of Disease in Childhood Fetal and Neonatal Edition

JF - Archives of Disease in Childhood Fetal and Neonatal Edition

IS - 1

ER -

S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery

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