(S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat

L. Groenink; J. Van Der Gugten; J. Mos; R.A.A. Maes; B. Olivier

doi:10.1016/0024-3205(94)00654-7

(S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat

L. Groenink, J. Van Der Gugten, J. Mos, R.A.A. Maes, B. Olivier

Solvay Pharmaceuticals

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The putative silent 5-HT(1A) receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT(1A) receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT(1A)-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.

Original language	English
Pages (from-to)	99-103
Number of pages	5
Journal	Life Sciences
Volume	55
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(94)00654-7
Publication status	Published - 18 Dec 1994

Keywords

(S)-U H301
corticosterone
plasma glucose
S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin
2 dipropylamino 5 fluoro 8 hydroxytetralin
glucose
partial agonist
serotonin 1A receptor
serotonin agonist
serotonin antagonist
agonist
animal experiment
article
controlled study
corticosterone blood level
glucose blood level
male
nonhuman
rat
subcutaneous drug administration

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title = "(S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat",

abstract = "The putative silent 5-HT(1A) receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT(1A) receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT(1A)-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.",

keywords = "(S)-U H301, corticosterone, plasma glucose, S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin, 2 dipropylamino 5 fluoro 8 hydroxytetralin, glucose, partial agonist, serotonin 1A receptor, serotonin agonist, serotonin antagonist, agonist, animal experiment, article, controlled study, corticosterone blood level, glucose blood level, male, nonhuman, rat, subcutaneous drug administration",

author = "L. Groenink and {Van Der Gugten}, J. and J. Mos and R.A.A. Maes and B. Olivier",

year = "1994",

month = dec,

day = "18",

doi = "10.1016/0024-3205(94)00654-7",

language = "English",

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T1 - (S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat

AU - Groenink, L.

AU - Van Der Gugten, J.

AU - Mos, J.

AU - Maes, R.A.A.

AU - Olivier, B.

PY - 1994/12/18

Y1 - 1994/12/18

N2 - The putative silent 5-HT(1A) receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT(1A) receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT(1A)-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.

AB - The putative silent 5-HT(1A) receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT(1A) receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT(1A)-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.

KW - (S)-U H301

KW - corticosterone

KW - plasma glucose

KW - S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin

KW - 2 dipropylamino 5 fluoro 8 hydroxytetralin

KW - glucose

KW - partial agonist

KW - serotonin 1A receptor

KW - serotonin agonist

KW - serotonin antagonist

KW - agonist

KW - animal experiment

KW - article

KW - controlled study

KW - corticosterone blood level

KW - glucose blood level

KW - male

KW - nonhuman

KW - rat

KW - subcutaneous drug administration

U2 - 10.1016/0024-3205(94)00654-7

DO - 10.1016/0024-3205(94)00654-7

M3 - Article

SN - 0024-3205

VL - 55

SP - 99

EP - 103

JO - Life Sciences

JF - Life Sciences

IS - 5

ER -

(S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat

Abstract

Keywords

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