Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties

D.J.M. Snelders; A. Casini; F. Edafe; G. van Koten; R.J.M. Klein Gebbink; P.J. Dyson

doi:10.1016/j.jorganchem.2010.11.025

Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties

D.J.M. Snelders
, A. Casini
, F. Edafe
, G. van Koten
, R.J.M. Klein Gebbink
, P.J. Dyson

extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L ¼ oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being þ3 and þ6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

Original language	English
Pages (from-to)	1108-1116
Number of pages	9
Journal	Journal of Organometallic Chemistry
Volume	696
Issue number	5
DOIs	https://doi.org/10.1016/j.jorganchem.2010.11.025
Publication status	Published - 2011

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioorganometallic chemistry
Ruthenium
Phosphine ligands
Metal-based drugs
DNA binding

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10.1016/j.jorganchem.2010.11.025

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title = "Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties",

abstract = "The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L ¼ oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being {\th}3 and {\th}6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.",

keywords = "Bioorganometallic chemistry, Ruthenium, Phosphine ligands, Metal-based drugs, DNA binding",

author = "D.J.M. Snelders and A. Casini and F. Edafe and \{van Koten\}, G. and \{Klein Gebbink\}, R.J.M. and P.J. Dyson",

year = "2011",

doi = "10.1016/j.jorganchem.2010.11.025",

language = "English",

volume = "696",

pages = "1108--1116",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties

AU - Snelders, D.J.M.

AU - Casini, A.

AU - Edafe, F.

AU - van Koten, G.

AU - Klein Gebbink, R.J.M.

AU - Dyson, P.J.

PY - 2011

Y1 - 2011

N2 - The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L ¼ oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being þ3 and þ6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

AB - The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L ¼ oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being þ3 and þ6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

KW - Bioorganometallic chemistry

KW - Ruthenium

KW - Phosphine ligands

KW - Metal-based drugs

KW - DNA binding

U2 - 10.1016/j.jorganchem.2010.11.025

DO - 10.1016/j.jorganchem.2010.11.025

M3 - Article

SN - 0022-328X

VL - 696

SP - 1108

EP - 1116

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 5

ER -

Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: synthesis, DNA interactions and in vitro properties

Abstract

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Keywords

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