Abstract
A Ruphos-mediated Suzuki cross-coupling between (hetero)aryl bromides and secondary alkyltrifluoroborates is described using palladium catalysis. The Ruphos ligand showed superior properties as compared to S-Phos in this type of reaction. This method constitutes a valuable extension to current methods for the straightforward production of secondary-alkylated (hetero)aryl derivatives. © 2008 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 4122-4124 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 26 |
DOIs | |
Publication status | Published - 23 Jun 2008 |
Keywords
- boric acid
- bromine derivative
- palladium
- article
- catalysis
- chemical reaction
- comparative study
- cross coupling reaction
- Suzuki reaction