Ruphos-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates

Adri van den Hoogenband, Jos H.M. Lange, Jan Willem Terpstra, Melle Koch, Gerben M. Visser, Martin Visser, Ties J. Korstanje, Johann T.B.H. Jastrzebski

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A Ruphos-mediated Suzuki cross-coupling between (hetero)aryl bromides and secondary alkyltrifluoroborates is described using palladium catalysis. The Ruphos ligand showed superior properties as compared to S-Phos in this type of reaction. This method constitutes a valuable extension to current methods for the straightforward production of secondary-alkylated (hetero)aryl derivatives. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4122-4124
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number26
DOIs
Publication statusPublished - 23 Jun 2008

Keywords

  • boric acid
  • bromine derivative
  • palladium
  • article
  • catalysis
  • chemical reaction
  • comparative study
  • cross coupling reaction
  • Suzuki reaction

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