Roads to the development of improved pertussis vaccines paved by immunology

Jolanda Brummelman; Mieszko M Wilk; Wanda G H Han; Cécile A C M van Els; Kingston H G Mills

doi:10.1093/femspd/ftv067

Roads to the development of improved pertussis vaccines paved by immunology

Jolanda Brummelman, Mieszko M Wilk, Wanda G H Han, Cécile A C M van Els, Kingston H G Mills

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protective immune responses when compared with immunization with acellular pertussis vaccines. Therefore, the immune responses induced with whole cell vaccine or after infection can be used as a benchmark for the development of third-generation vaccines against pertussis. Here, we review the literature on the immunology of B. pertussis infection and vaccination and discuss the lessons learned that will help in the design of improved pertussis vaccines.

Original language	English
Article number	ftv067
Journal	Pathogens and Disease
Volume	73
Issue number	8
Early online date	Nov 2015
DOIs	https://doi.org/10.1093/femspd/ftv067
Publication status	Published - Nov 2015

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10.1093/femspd/ftv067

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title = "Roads to the development of improved pertussis vaccines paved by immunology",

abstract = "Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protective immune responses when compared with immunization with acellular pertussis vaccines. Therefore, the immune responses induced with whole cell vaccine or after infection can be used as a benchmark for the development of third-generation vaccines against pertussis. Here, we review the literature on the immunology of B. pertussis infection and vaccination and discuss the lessons learned that will help in the design of improved pertussis vaccines.",

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AU - Brummelman, Jolanda

AU - Wilk, Mieszko M

AU - Han, Wanda G H

AU - van Els, Cécile A C M

AU - Mills, Kingston H G

PY - 2015/11

Y1 - 2015/11

N2 - Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protective immune responses when compared with immunization with acellular pertussis vaccines. Therefore, the immune responses induced with whole cell vaccine or after infection can be used as a benchmark for the development of third-generation vaccines against pertussis. Here, we review the literature on the immunology of B. pertussis infection and vaccination and discuss the lessons learned that will help in the design of improved pertussis vaccines.

AB - Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protective immune responses when compared with immunization with acellular pertussis vaccines. Therefore, the immune responses induced with whole cell vaccine or after infection can be used as a benchmark for the development of third-generation vaccines against pertussis. Here, we review the literature on the immunology of B. pertussis infection and vaccination and discuss the lessons learned that will help in the design of improved pertussis vaccines.

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ER -

Roads to the development of improved pertussis vaccines paved by immunology

Abstract

Bibliographical note

UN SDGs

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