Roadmap towards safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)

Flemming R. Cassee*, Eric A.J. Bleeker, Cyrille Durand, Thomas Exner, Andreas Falk, Steffi Friedrichs, Elisabeth Heunisch, Martin Himly, Sabine Hofer, Norbert Hofstätter, Danail Hristozov, Penny Nymark, Anna Pohl, Lya G. Soeteman-Hernández, Blanca Suarez-Merino, Eugenia Valsami-Jones, Monique Groenewold

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


The adoption of innovative advanced materials holds vast potential, contingent upon addressing safety and sustainability concerns. The European Commission advocates the integration of Safe and Sustainable by Design (SSbD) principles early in the innovation process to streamline market introduction and mitigate costs. Within this framework, encompassing ecological, social, and economic factors is paramount. The NanoSafety Cluster (NSC) delineates key safety and sustainability areas, pinpointing unresolved issues and research gaps to steer the development of safe(r) materials. Leveraging FAIR data management and integration, alongside the alignment of regulatory aspects, fosters informed decision-making and innovation. Integrating circularity and sustainability mandates clear guidance, ensuring responsible innovation at every stage. Collaboration among stakeholders, anticipation of regulatory demands, and a commitment to sustainability are pivotal for translating SSbD into tangible advancements. Harmonizing standards and test guidelines, along with regulatory preparedness through an exchange platform, is imperative for governance and market readiness. By adhering to these principles, the effective and sustainable deployment of innovative materials can be realized, propelling positive transformation and societal acceptance.

Original languageEnglish
Pages (from-to)105-126
Number of pages22
JournalComputational and Structural Biotechnology Journal
Publication statusPublished - Dec 2024


  • Advanced materials
  • FAIR data management
  • Harmonization
  • Innovative materials
  • Nanomaterials
  • Regulatory preparedness
  • Safe-by-design
  • Standardization
  • Sustainability


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