TY - JOUR
T1 - RNA topology remolds electrostatic stabilization of viruses
AU - Erdemci-Tandogan, Gonca
AU - Wagner, Jef
AU - Van Der Schoot, Paul
AU - Podgornik, Rudolf
AU - Zandi, Roya
PY - 2014/3/14
Y1 - 2014/3/14
N2 - Simple RNA viruses efficiently encapsulate their genome into a nano-sized protein shell: the capsid. Spontaneous coassembly of the genome and the capsid proteins is driven predominantly by electrostatic interactions between the negatively charged RNA and the positively charged inner capsid wall. Using field theoretic formulation we show that the inherently branched RNA secondary structure allows viruses to maximize the amount of encapsulated genome and make assembly more efficient, allowing viral RNAs to out-compete cellular RNAs during replication in infected host cells.
AB - Simple RNA viruses efficiently encapsulate their genome into a nano-sized protein shell: the capsid. Spontaneous coassembly of the genome and the capsid proteins is driven predominantly by electrostatic interactions between the negatively charged RNA and the positively charged inner capsid wall. Using field theoretic formulation we show that the inherently branched RNA secondary structure allows viruses to maximize the amount of encapsulated genome and make assembly more efficient, allowing viral RNAs to out-compete cellular RNAs during replication in infected host cells.
UR - http://www.scopus.com/inward/record.url?scp=84898961689&partnerID=8YFLogxK
U2 - 10.1103/PhysRevE.89.032707
DO - 10.1103/PhysRevE.89.032707
M3 - Article
AN - SCOPUS:84898961689
SN - 1539-3755
VL - 89
JO - Physical Review. E, Statistical, nonlinear, and soft matter physics
JF - Physical Review. E, Statistical, nonlinear, and soft matter physics
IS - 3
M1 - 032707
ER -