Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

Olivia Febvey; Joachim Schüz; Helen D Bailey; Jacqueline Clavel; Brigitte Lacour; Laurent Orsi; Tracy Lightfoot; Eve Roman; Roel Vermeulen; Hans Kromhout; Ann Olsson

doi:10.1097/JOM.0000000000000852

Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

Olivia Febvey, Joachim Schüz, Helen D Bailey, Jacqueline Clavel, Brigitte Lacour, Laurent Orsi, Tracy Lightfoot, Eve Roman, Roel Vermeulen, Hans Kromhout, Ann Olsson

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.

METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).

CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

Original language	English
Pages (from-to)	1046-1052
Number of pages	7
Journal	Journal of Occupational and Environmental Medicine
Volume	58
Issue number	10
DOIs	https://doi.org/10.1097/JOM.0000000000000852
Publication status	Published - Oct 2016

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Febvey, O., Schüz, J., Bailey, H. D., Clavel, J., Lacour, B., Orsi, L., Lightfoot, T., Roman, E., Vermeulen, R., Kromhout, H., & Olsson, A. (2016). Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies. Journal of Occupational and Environmental Medicine, 58(10), 1046-1052. https://doi.org/10.1097/JOM.0000000000000852

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title = "Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies",

abstract = "OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.",

author = "Olivia Febvey and Joachim Sch{\"u}z and Bailey, {Helen D} and Jacqueline Clavel and Brigitte Lacour and Laurent Orsi and Tracy Lightfoot and Eve Roman and Roel Vermeulen and Hans Kromhout and Ann Olsson",

year = "2016",

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doi = "10.1097/JOM.0000000000000852",

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Febvey, O, Schüz, J, Bailey, HD, Clavel, J, Lacour, B, Orsi, L, Lightfoot, T, Roman, E, Vermeulen, R , Kromhout, H & Olsson, A 2016, 'Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies', Journal of Occupational and Environmental Medicine, vol. 58, no. 10, pp. 1046-1052. https://doi.org/10.1097/JOM.0000000000000852

Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies. / Febvey, Olivia; Schüz, Joachim; Bailey, Helen D et al.
In: Journal of Occupational and Environmental Medicine, Vol. 58, No. 10, 10.2016, p. 1046-1052.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

AU - Febvey, Olivia

AU - Schüz, Joachim

AU - Bailey, Helen D

AU - Clavel, Jacqueline

AU - Lacour, Brigitte

AU - Orsi, Laurent

AU - Lightfoot, Tracy

AU - Roman, Eve

AU - Vermeulen, Roel

AU - Kromhout, Hans

AU - Olsson, Ann

PY - 2016/10

Y1 - 2016/10

N2 - OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

AB - OBJECTIVE: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.METHODS: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).CONCLUSION: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.

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DO - 10.1097/JOM.0000000000000852

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SN - 1076-2752

VL - 58

SP - 1046

EP - 1052

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 10

ER -

Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies

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