Risk of cataract and glaucoma in patients with multiple sclerosis

Marloes T Bazelier; Sigrid Mueller-Schotte; Hubert G M Leufkens; Bernard M J Uitdehaag; Tjeerd van Staa; Frank de Vries

doi:10.1177/1352458511426737

Risk of cataract and glaucoma in patients with multiple sclerosis

Marloes T Bazelier, Sigrid Mueller-Schotte, Hubert G M Leufkens, Bernard M J Uitdehaag, Tjeerd van Staa, Frank de Vries

Pharmacoepidemiology and Clinical Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.

METHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.

RESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93).

CONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.

Original language	English
Pages (from-to)	628-638
Number of pages	11
Journal	Multiple Sclerosis Journal
Volume	18
Issue number	5
DOIs	https://doi.org/10.1177/1352458511426737
Publication status	Published - 2012

Keywords

Adolescent
Adult
Age Factors
Case-Control Studies
Cataract
Disease-Free Survival
England
Female
Glaucoma
Glucocorticoids
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Multiple Sclerosis
Proportional Hazards Models
Registries
Risk Assessment
Risk Factors
Sex Factors
Time Factors
Young Adult

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10.1177/1352458511426737

Cite this

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title = "Risk of cataract and glaucoma in patients with multiple sclerosis",

abstract = "BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.METHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.RESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93).CONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.",

keywords = "Adolescent, Adult, Age Factors, Case-Control Studies, Cataract, Disease-Free Survival, England, Female, Glaucoma, Glucocorticoids, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Multiple Sclerosis, Proportional Hazards Models, Registries, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Young Adult",

author = "Bazelier, {Marloes T} and Sigrid Mueller-Schotte and Leufkens, {Hubert G M} and Uitdehaag, {Bernard M J} and {van Staa}, Tjeerd and {de Vries}, Frank",

year = "2012",

doi = "10.1177/1352458511426737",

language = "English",

volume = "18",

pages = "628--638",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "5",

}

TY - JOUR

T1 - Risk of cataract and glaucoma in patients with multiple sclerosis

AU - Bazelier, Marloes T

AU - Mueller-Schotte, Sigrid

AU - Leufkens, Hubert G M

AU - Uitdehaag, Bernard M J

AU - van Staa, Tjeerd

AU - de Vries, Frank

PY - 2012

Y1 - 2012

N2 - BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.METHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.RESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93).CONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.

AB - BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.METHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.RESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93).CONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Case-Control Studies

KW - Cataract

KW - Disease-Free Survival

KW - England

KW - Female

KW - Glaucoma

KW - Glucocorticoids

KW - Humans

KW - Incidence

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Proportional Hazards Models

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Sex Factors

KW - Time Factors

KW - Young Adult

U2 - 10.1177/1352458511426737

DO - 10.1177/1352458511426737

M3 - Article

C2 - 22025330

SN - 1352-4585

VL - 18

SP - 628

EP - 638

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 5

ER -

Risk of cataract and glaucoma in patients with multiple sclerosis

Abstract

Keywords

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