Risicofactoren voor inactiviteit bij patiënten met ernstige psychiatrische aandoeningen in de langdurige zorg

Translated title of the contribution: Risk factors for inactivity in patients in long-term care with severe mental illness

Diederik E. Tenback, F. Van Kessel, J. Jessurun, Y.J. Pijl, E.R. Heerdink, P.N. Van Harten

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Inactivity is a major problem in long-stay patients with severe mental illness. Very little research has been done into the variables that can predict and explain this inactivity. AIM: To find associations between inactivity and the variables (psychiatric, pharmacological, lifestyle and comorbidity) of patients with severe mental health illness. METHODS: A cross-sectional study was performed at 'Zon en Schild', a centre for mental health care in Amersfoort in the Netherlands. The study included too long-stay psychiatric patients hospitalized throughout the period February 2011 till July 2011. All of these patients were being treated with antipsychotics and were long-term inpatients at a psychiatric clinic. At the out-patient clinic of 'Zon en Schild' they were screened for inactivity via a subscale of the Nurses' Observation Scale for Inpatient Evaluation (NOSIE-30). Data were collected and analysed by means of a validated questionnaire, physical examination and patient records. Simple and multiple regression analyses were performed in order to find associated factors associated with inactivity. RESULTS: We found that 31.3% of the variance predicted by the multiple regression analysis model for inactivity was associated with the variables parkinsonism, negative Symptoms, metabolic syndrome, diabetes, body-mass index (BMI), first-generation antipsychotics and combination of first- and second-generation antipsychotics. Age (β=0.235, P=0.04) and a combination therapy involving traditional and atypical antipsychotics (β=0.317, p=0.04) were significantly associated with inactivity. CONCLUSION: Age and the combination of first- and second-generation antipsychotics were associated with inactivity. Cross-sectional studies do not demonstrate any causal links, but can generate a hypothesis. One possible hypothesis for the surprising link between inactivity and the combination of traditional and atypical antipsychotics is that the combination of antipsychotics promotes and fosters inactivity.
Translated title of the contributionRisk factors for inactivity in patients in long-term care with severe mental illness
Original languageDutch
Pages (from-to)83-91
Number of pages9
JournalTijdschrift voor Psychiatrie
Issue number2
Publication statusPublished - 1 Jan 2013


  • Clinical
  • Epidemiology
  • Inactivity
  • Long-term care
  • Schizophrenia
  • atypical antipsychotic agent
  • neuroleptic agent
  • article
  • body mass
  • comorbidity
  • diabetes mellitus
  • disease severity
  • hospital patient
  • human
  • immobilization
  • lifestyle
  • long term care
  • major clinical study
  • medical record
  • mental disease
  • mental health care
  • mental hospital
  • mental patient
  • metabolic syndrome X
  • negative syndrome
  • nurses observation scale for inpatient evaluation scale
  • outpatient
  • parkinsonism
  • physical examination
  • psychiatric treatment
  • psychiatry
  • questionnaire
  • rating scale
  • risk factor


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